Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 3/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.35 |
| ▸ | MMP1 | P03956 | 2/20 | 0.31 |
| ▸ | MMP13 | P45452 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1900032 | 1.00 | RAPGEF4 (0.44) | RAPGEF4ALDH1A1FFAR4GABRG2GABRB3 | |
| SCHEMBL20874147 | 0.87 | RAPGEF4 (0.40) | RAPGEF4FFAR4LMNATSHRF2 | |
| SCHEMBL21816738 | 0.86 | RAPGEF4 (0.41) | RAPGEF4ALDH1A1FFAR4GABRG2GABRB3 | |
| SCHEMBL27216120 | 0.85 | RAPGEF4 (0.46) | RAPGEF4ALDH1A1FFAR4GABRG2GABRB3 | |
| SCHEMBL31153489 | 0.84 | RAPGEF4 (0.38) | RAPGEF4ALDH1A1F2PRSS1PRSS2 | |
| SCHEMBL29032827 | 0.84 | RAPGEF4 (0.44) | RAPGEF4ALDH1A1FFAR4GABRG2GABRB3 | |
| SCHEMBL16913904 | 0.82 | RAPGEF4 (0.36) | RAPGEF4F2PRSS1PRSS2PRSS3 | |
| SCHEMBL23320398 | 0.81 | RAPGEF4 (0.35) | RAPGEF4FFAR4F2PRSS1PRSS2 | |
| SCHEMBL29010579 | 0.80 | MMP13 (0.43) | RAPGEF4SMN1; SMN2MMP1MMP13CA1 | |
| SCHEMBL25283314 | 0.80 | F2 (0.37) | RAPGEF4ALDH1A1LMNATSHRF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315824-B | Preparation method of 6-bromo-4-methoxypyrazolo [1,5-a ] pyridine-3-carbonitrile | 南京药石科技股份有限公司 | 2025-03-07 | — | — | CN | claimed |
| CN-114315824-A | Preparation method of 6-bromo-4-methoxy pyrazolo [1,5-a ] pyridine-3-carbonitrile | 南京药石科技股份有限公司 | 2022-04-12 | — | — | CN | claimed |
| CN-115772170-B | Pyrazolo [1,5-a ] pyridine derivative and preparation method and application thereof | 徐诺药业(南京)有限公司 | 2025-05-16 | — | — | CN | disclosed |
| CN-114315824-B | Preparation method of 6-bromo-4-methoxypyrazolo [1,5-a ] pyridine-3-carbonitrile | 南京药石科技股份有限公司 | 2025-03-07 | — | — | CN | disclosed |
| CN-114163437-B | Substituted pyrazolo [1,5-a ] pyridine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2025-03-04 | — | — | CN | disclosed |
| CN-118319866-A | Formulations comprising RET kinase inhibitors | 罗索肿瘤学公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-114380825-B | Substituted pyrazole condensed ring derivative and preparation method and application thereof | 北京志健金瑞生物医药科技有限公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-114907338-B | Nitrogen-containing polycyclic condensed ring compound, pharmaceutical composition, preparation method and application thereof | 北京志健金瑞生物医药科技有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-111263760-B | Method for preparing a compound | 奥瑞生物药品公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-113490670-B | Nitrogen-containing polycyclic condensed ring compound, pharmaceutical composition, preparation method and application thereof | 北京志健金瑞生物医药科技有限公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-112771043-B | Substituted pyrazole condensed ring derivative and preparation method and application thereof | 北京志健金瑞生物医药科技有限公司 | 2023-04-28 | — | — | CN | disclosed |
| CN-115772170-A | Pyrazolo [1,5-a ] pyridine derivative and preparation method and application thereof | 徐诺药业(南京)有限公司 | 2023-03-10 | — | — | CN | disclosed |
| CN-114907338-A | Nitrogen-containing polycyclic fused ring compound, and pharmaceutical composition, preparation method and application thereof | 北京志健金瑞生物医药科技有限公司 | 2022-08-16 | — | — | CN | disclosed |
| CN-108349969-B | Substituted pyrazolo [1,5-a ] pyridine compounds as RET kinase inhibitors | 阵列生物制药公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114380825-A | Substituted pyrazole fused ring derivative and preparation method and application thereof | 北京志健金瑞生物医药科技有限公司 | 2022-04-22 | — | — | CN | disclosed |
| CN-114315824-A | Preparation method of 6-bromo-4-methoxy pyrazolo [1,5-a ] pyridine-3-carbonitrile | 南京药石科技股份有限公司 | 2022-04-12 | — | — | CN | disclosed |