Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 6/20 | 0.59 |
| ▸ | PRKCB | P05771 | 5/20 | 0.59 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.59 |
| ▸ | PRKCH | P24723 | 3/20 | 0.59 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.59 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.59 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.52 |
| ▸ | PRKACA | P17612 | 3/20 | 0.46 |
| ▸ | PRKACG | P22612 | 3/20 | 0.46 |
| ▸ | PRKACB | P22694 | 3/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 5/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2955891 | 0.93 | PRKCA (0.59) | PRKCAPRKCBPRKCEPRKCHPRKCQ | |
| SCHEMBL4740368 | 0.90 | PRKCA (0.67) | PRKCAPRKCBPRKCEPRKCHPRKCQ | |
| SCHEMBL4680242 | 0.88 | PRKCA (0.72) | PRKCAPRKCBPRKCEPRKCHPRKCQ | |
| SCHEMBL13166896 | 0.88 | PRKCA (0.65) | PRKCAPRKCBPRKCEPRKCHPRKCQ | |
| SCHEMBL2954303 | 0.87 | PRKCA (0.59) | PRKCAPRKCBPRKCEPRKCHPRKCQ | |
| SCHEMBL4680012 | 0.85 | PRKCA (0.61) | PRKCAPRKCBPRKCEPRKCHPRKCQ | |
| SCHEMBL2945607 | 0.85 | PRKCA (0.81) | PRKCAPRKCBPRKCEPRKCHPRKCQ | |
| SCHEMBL4679963 | 0.84 | PRKCA (0.41) | PRKCAPRKCBPRKCEPRKCHPRKCQ | |
| SCHEMBL4675316 | 0.83 | PRKCA (0.56) | PRKCAPRKCBPRKCEPRKCHPRKCQ | |
| SCHEMBL4676611 | 0.82 | PRKCA (0.65) | PRKCAPRKCBPRKCEPRKCHPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240650-A1 | SUBSTITUTED PYRROLINES AS KINASE INHIBITORS | ZHANG HAN-CHENG | 2010-09-23 | — | — | US | disclosed |
| US-7759380-B2 | Substituted pyrrolines as kinase inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2010-07-20 | — | — | US | disclosed |
| US-7608634-B2 | Substituted pyrrolines as kinase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2009-10-27 | — | — | US | disclosed |
| EP-1513520-B1 | SUBSTITUTED PYRROLINES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-09-24 | — | — | EP | disclosed |
| US-20070213386-A1 | Substituted pyrrolines as kinase inhibitors | ZHANG HAN-CHENG | 2007-09-13 | — | — | US | disclosed |
| US-20070213387-A1 | Substituted pyrrolines as kinase inhibitors | ZHANG HAN-CHENG | 2007-09-13 | — | — | US | disclosed |
| US-7232906-B2 | Substituted pyrrolines as kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BG) | 2007-06-19 | — | — | US | disclosed |
| US-20040054180-A1 | Substituted pyrrolines as kinase inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2004-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240650-A1 | SUBSTITUTED PYRROLINES AS KINASE INHIBITORS | PRKDC, MAP2K2, TTK | PRKCA 59/4885PRKCB 55/4885PRKCE 53/4885 |
| US-20070213387-A1 | Substituted pyrrolines as kinase inhibitors | PRKDC, MAP2K2, TTK | PRKCA 59/4885PRKCB 55/4885PRKCE 53/4885 |
| US-20040054180-A1 | Substituted pyrrolines as kinase inhibitors | PRKDC, MAP2K2, TTK | PRKCA 59/4885PRKCB 55/4885PRKCE 53/4885 |
| US-20070213386-A1 | Substituted pyrrolines as kinase inhibitors | PRKDC, MAP2K2, TTK | PRKCA 59/4885PRKCB 55/4885PRKCE 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.