Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22950325 | 0.91 | GPR119 (0.41) | GPR119CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL29662060 | 0.91 | GPR119 (0.41) | GPR119CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL20520705 | 0.79 | OPRD1 (0.42) | GPR119CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL28692347 | 0.75 | CYP2D6 (0.41) | CYP3A4CYP2D6CYP2C19LMNAMEN1 | |
| SCHEMBL27619332 | 0.74 | GPR119 (0.48) | GPR119CYP2C19JAK2JAK1MEN1 | |
| SCHEMBL30989078 | 0.74 | OPRD1 (0.53) | CYP3A4CYP2D6CYP2C9CYP2C19OPRD1 | |
| SCHEMBL16862236 | 0.72 | CYP2D6 (0.51) | GPR119CYP3A4CYP2D6CYP2C19OPRD1 | |
| SCHEMBL965515 | 0.72 | LMNA (0.62) | LMNAMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL30989110 | 0.72 | OPRD1 (0.50) | GPR119CYP3A4CYP2D6CYP2C19OPRD1 | |
| SCHEMBL9345760 | 0.72 | OPRD1 (0.46) | GPR119OPRD1OPRK1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4003997-A1 | DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2022-06-01 | — | — | EP | disclosed |
| CN-114174300-A | Dihydropyrimidine derivatives and their use in the treatment of HBV infection or HBV-induced diseases | 杨森科学爱尔兰无限公司 | 2022-03-11 | — | — | CN | disclosed |