Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 12/20 | 0.41 |
| ▸ | AKT2 | P31751 | 6/20 | 0.41 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.31 |
| ▸ | TEK | Q02763 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25346421 | 1.00 | AKT1 (0.41) | AKT1AKT2AKT3DGAT1PDE10A | |
| SCHEMBL25345729 | 0.87 | RAB9A (0.36) | DGAT1PDE10AMAPTEGFRIGF1R | |
| SCHEMBL29513537 | 0.87 | RAB9A (0.36) | DGAT1PDE10AMAPTEGFRIGF1R | |
| SCHEMBL29514144 | 0.86 | DYRK1A (0.35) | DGAT1PDE10AMAPTEGFRIGF1R | |
| SCHEMBL25345996 | 0.86 | DYRK1A (0.35) | DGAT1PDE10AMAPTEGFRIGF1R | |
| SCHEMBL29513687 | 0.86 | METAP2 (0.36) | DGAT1 | |
| SCHEMBL25345873 | 0.86 | METAP2 (0.36) | DGAT1 | |
| SCHEMBL25346910 | 0.84 | DGAT1 (0.34) | DGAT1PDE10AMAPTEGFRIGF1R | |
| SCHEMBL25345529 | 0.83 | DGAT1 (0.33) | DGAT1MAPT | |
| SCHEMBL29514016 | 0.83 | DGAT1 (0.33) | DGAT1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076973-A1 | 7-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |