Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 10/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | CD44 | P16070 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28109514 | 0.81 | PNMT (0.61) | PNMTDRD2DRD3ASIC3HTR2A | |
| SCHEMBL25324819 | 0.79 | PNMT (0.53) | PNMTDRD2DRD3ASIC3HTR2A | |
| SCHEMBL30474289 | 0.79 | PNMT (0.53) | PNMTDRD2DRD3ASIC3HTR2A | |
| Hydrochloric Acid SCHEMBL7641237 | 0.78 | PNMT (0.51) | PNMTDRD2DRD3ASIC3HTR2A | |
| SCHEMBL15301098 | 0.74 | ALDH1A1 (0.49) | PNMTDRD2DRD3HTR2AHTR2C | |
| SCHEMBL18554679 | 0.73 | PRCP (0.51) | PNMTDRD2DRD3ASIC3ADRA2A | |
| SCHEMBL28999502 | 0.73 | PNMT (0.50) | PNMTDRD2DRD3HTR2AHTR2C | |
| SCHEMBL31391697 | 0.73 | PNMT (0.50) | PNMTDRD2DRD3HTR2AHTR2C | |
| SCHEMBL31139061 | 0.73 | PNMT (0.52) | PNMTDRD2DRD3ASIC3HTR2A | |
| SCHEMBL3004226 | 0.73 | PNMT (0.52) | PNMTDRD2DRD3ASIC3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240363-A1 | 7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1 | Merck Sharp & Dohme LLC (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022098806-A1 | 7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1 | MERCK SHARP & DOHME CORP. (US) | 2022-05-12 | — | — | WO | disclosed |