Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.39 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aristolochic Acid Ii SCHEMBL571697 | 1.00 | CDK2 (0.77) | CDK2ALDH1A1MAPTCYP3A4SMN1; SMN2 | |
| Aristolochic Acid C SCHEMBL30039516 | 0.87 | CDK2 (1.00) | CDK2ALDH1A1MAPTCYP3A4SMN1; SMN2 | |
| Aristolochic Acid C SCHEMBL30697302 | 0.87 | CDK2 (1.00) | CDK2ALDH1A1MAPTCYP3A4SMN1; SMN2 | |
| Aristolochic Acid Iii SCHEMBL30568104 | 0.84 | CDK2 (1.00) | CDK2ALDH1A1MAPTCYP3A4SMN1; SMN2 | |
| SCHEMBL7456768 | 0.83 | CDK2 (0.68) | CDK2ALDH1A1MAPTCYP3A4SMN1; SMN2 | |
| Aristolochic Acid SCHEMBL30825061 | 0.81 | ALDH1A1 (1.00) | CDK2ALDH1A1MAPTCYP3A4SMN1; SMN2 | |
| Aristolochic Acid SCHEMBL29367530 | 0.81 | ALDH1A1 (1.00) | CDK2ALDH1A1MAPTCYP3A4SMN1; SMN2 | |
| Aristolochic Acid SCHEMBL29518476 | 0.81 | ALDH1A1 (1.00) | CDK2ALDH1A1MAPTCYP3A4SMN1; SMN2 | |
| Aristolochic Acid SCHEMBL15535358 | 0.80 | ALDH1A1 (0.98) | CDK2ALDH1A1MAPTCYP3A4SMN1; SMN2 | |
| 7-Hydroxy Aristolochic A SCHEMBL4557492 | 0.76 | CDK2 (1.00) | CDK2ALDH1A1MAPTCYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114624376-B | Method for detecting aristolochic acid I-DNA adducts in tissues | 中国科学院上海药物研究所 | 2024-10-11 | — | — | CN | claimed |
| CN-113252810-B | Method for determining content of 6 aristolochic acid components in asarum | 河北省药品医疗器械检验研究院(河北省化妆品检验研究中心) | 2023-04-07 | — | — | CN | claimed |
| CN-115494177-A | Method for detecting concentration of six components in angelica Sini decoction in blood plasma | 广州医药研究总院有限公司 | 2022-12-20 | — | — | CN | claimed |
| CN-112432990-B | Method for analyzing aristolochic acid and/or aristoloclactam | 岛津企业管理（中国）有限公司 | 2022-12-02 | — | — | CN | claimed |
| CN-114624376-A | Method for detecting aristolochic acid I-DNA adduct in tissue | 中国科学院上海药物研究所 | 2022-06-14 | — | — | CN | claimed |
| CN-114487203-A | Method for detecting aristolochic acid in houttuynia cordata based on metal organic framework material dispersion solid-phase extraction combined with high performance liquid chromatography | 南昌大学 | 2022-05-13 | — | — | CN | claimed |
| CN-116554139-B | Preparation method of reference substance of aristolochic acid D | 上海诗丹德标准技术服务有限公司 | 2025-05-06 | — | — | CN | disclosed |
| WO-2024217571-A1 | METHOD FOR PREPARING REFERENCE SUBSTANCE OF ARISTOLOCHIC ACID D | 上海诗丹德标准技术服务有限公司 | 2024-10-24 | — | — | WO | disclosed |
| CN-114624376-B | Method for detecting aristolochic acid I-DNA adducts in tissues | 中国科学院上海药物研究所 | 2024-10-11 | — | — | CN | disclosed |
| CN-117471003-B | Separation and quantitative detection method for aristolochic acid component in houttuynia cordata and application thereof | 中国中医科学院中药研究所 | 2024-10-08 | — | — | CN | disclosed |
| CN-117805273-B | Quantitative detection method and application of 5 aristolochic acid substances in diarrhea-relieving capsule | 浙江苏可安药业有限公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-117448445-B | Application of PTEN, TSC1 and TSC2 genes in aristolochic acid sensitivity detection | 中国中医科学院中药研究所 | 2024-04-09 | — | — | CN | disclosed |
| CN-117805273-A | Quantitative detection method and application of 5 aristolochic acid substances in diarrhea-relieving capsule | 浙江苏可安药业有限公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115494177-A | Method for detecting concentration of six components in angelica Sini decoction in blood plasma | 广州医药研究总院有限公司 | 2022-12-20 | — | — | CN | disclosed |
| CN-115494177-A | Method for detecting concentration of six components in angelica Sini decoction in blood plasma | 广州医药研究总院有限公司 | 2022-12-20 | — | — | CN | disclosed |
| CN-112432990-B | Method for analyzing aristolochic acid and/or aristoloclactam | 岛津企业管理（中国）有限公司 | 2022-12-02 | — | — | CN | disclosed |
| CN-114469930-B | Application of aristolochic acid IVa in preparing anti-histamine or pneumonia treatment medicine | 中国中医科学院中药研究所 | 2022-07-05 | — | — | CN | disclosed |
| CN-114624376-A | Method for detecting aristolochic acid I-DNA adduct in tissue | 中国科学院上海药物研究所 | 2022-06-14 | — | — | CN | disclosed |
| CN-114469930-A | Application of aristolochic acid IVa in preparing antihistaminic or pneumonia treatment medicine | 中国中医科学院中药研究所 | 2022-05-13 | — | — | CN | disclosed |
| CN-114487203-A | Method for detecting aristolochic acid in houttuynia cordata based on metal organic framework material dispersion solid-phase extraction combined with high performance liquid chromatography | 南昌大学 | 2022-05-13 | — | — | CN | disclosed |