Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | CA4 | P22748 | 3/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | LDHB | P07195 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA5A | P35218 | 2/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL2951917 | 1.00 | ACHE (0.58) | ACHECA4LDHALDHBLMNA | |
| Phosphoric Acid SCHEMBL8439606 | 0.96 | ACHE (0.64) | ACHECA4LDHALDHBLMNA | |
| Phosphoric Acid SCHEMBL295826 | 0.96 | — | — | |
| Phosphoric Acid SCHEMBL28655975 | 0.92 | ACHE (0.58) | ACHECA4LDHALDHBLMNA | |
| Phosphoric Acid SCHEMBL28930096 | 0.92 | ACHE (0.58) | ACHECA4LDHALDHBLMNA | |
| Phosphoric Acid SCHEMBL825552 | 0.87 | LMNA (0.55) | ACHECA4LDHALDHBLMNA | |
| Phosphoric Acid SCHEMBL8841102 | 0.87 | LMNA (0.55) | ACHECA4LDHALDHBLMNA | |
| Phosphoric Acid SCHEMBL825556 | 0.87 | LMNA (0.55) | ACHECA4LDHALDHBLMNA | |
| Phosphoric Acid SCHEMBL28395102 | 0.87 | LMNA (0.55) | ACHECA4LDHALDHBLMNA | |
| Phosphoric Acid SCHEMBL28121479 | 0.87 | LMNA (0.55) | ACHECA4LDHALDHBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7753056-B2 | Smokable rod for a cigarette | R. J. REYNOLDS TOBACCO COMPANY (US) | 2010-07-13 | — | — | US | disclosed |
| US-20090151739-A1 | Smokable Rod for a Cigarette | BORSCHKE AUGUST JOSEPH | 2009-06-18 | — | — | US | disclosed |
| US-7503330-B2 | Smokable rod for a cigarette | R.J. REYNOLDS TOBACCO COMPANY (US) | 2009-03-17 | — | — | US | disclosed |
| EP-1670326-B1 | SMOKABLE ROD FOR A CIGARETTE | REYNOLDS TOBACCO CO R (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1670326-A1 | SMOKABLE ROD FOR A CIGARETTE | R.J. REYNOLDS TOBACCO COMPANY (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005032285-A1 | SMOKABLE ROD FOR A CIGARETTE | R. J. REYNOLDS TOBACCO COMPANY (US) | 2005-04-14 | — | — | WO | disclosed |
| US-20050066986-A1 | Smokable rod for a cigarette | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2005-03-31 | — | — | US | disclosed |
| US-20050066985-A1 | Smokable rod for a cigarette | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2005-03-31 | — | — | US | disclosed |