Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.78 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.70 |
| ▸ | TUBB | P07437 | 6/20 | 0.70 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.70 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.70 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.70 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.70 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.70 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.70 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.70 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.70 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.70 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.70 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.70 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.70 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | NME2 | P22392 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isaindigotone SCHEMBL29519815 | 0.88 | ALOX5 (1.00) | ALOX5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL21931930 | 0.86 | ALOX5 (0.63) | ALOX5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29519687 | 0.85 | TUBB4A (0.67) | ALOX5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29520035 | 0.83 | ALOX5 (0.65) | ALOX5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29519684 | 0.82 | ALOX5 (0.88) | ALOX5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29519827 | 0.82 | RAB9A (0.66) | ALOX5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29519683 | 0.79 | MEN1 (0.60) | ALOX5RAB9ANPC1NME2MEN1 | |
| SCHEMBL11112931 | 0.79 | ALOX5 (0.65) | ALOX5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL11112929 | 0.79 | ALOX5 (0.65) | ALOX5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL31284384 | 0.79 | MEN1 (0.55) | ALOX5TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114249733-B | Isaindigotone derivative and application thereof in preparation of antitumor drugs | 兰州大学 | 2023-05-12 | — | — | CN | disclosed |
| CN-114249733-A | Isaindigotone derivative and application thereof in preparation of antitumor drugs | 兰州大学 | 2022-03-29 | — | — | CN | disclosed |