Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 2/20 | 0.58 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.55 |
| ▸ | VCP | P55072 | 4/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13973141 | 1.00 | PRKCI (0.58) | PRKCINAPRTCHIAVCPP2RX7 | |
| SCHEMBL11538362 | 0.87 | PRKCI (0.55) | PRKCINAPRTVCPP2RX7HPGD | |
| SCHEMBL28765983 | 0.83 | PRKCI (0.58) | PRKCINAPRTVCPP2RX7PIK3CD | |
| SCHEMBL922505 | 0.83 | HPGD (0.54) | PRKCIVCPHPGDKDM4EALDH1A1 | |
| SCHEMBL26693008 | 0.82 | P2RX7 (0.66) | PRKCINAPRTVCPP2RX7KDM4E | |
| SCHEMBL921161 | 0.82 | HPGD (0.56) | PRKCINAPRTVCPHPGDKDM4E | |
| SCHEMBL4260512 | 0.82 | PRKCI (0.56) | PRKCINAPRTVCPP2RX7PIK3CD | |
| SCHEMBL27863536 | 0.81 | MAPK1 (0.54) | PRKCINAPRTP2RX7HPGDALDH1A1 | |
| SCHEMBL28115710 | 0.81 | PRKCI (0.52) | PRKCINAPRTVCPP2RX7PIK3CD | |
| SCHEMBL5418289 | 0.81 | P2RX7 (0.70) | CHIAP2RX7HPGDKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502549-B | Homopiperazinyl and homopiperidinyl quinazolin-4 (3H) -one derivatives having multimodal activity against pain | 埃斯特韦制药股份公司 | 2024-10-25 | — | — | CN | disclosed |
| EP-4041391-A1 | HOMOPIPERAZINYL AND HOMOPIPERIDINYL QUINAZOLIN-4(3H)-ONE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2022-08-17 | — | — | EP | disclosed |
| CN-114502549-A | Homopiperazinyl and homopiperidinyl quinazolin-4 (3H) -one derivatives having multimodal activity against pain | 埃斯特韦制药股份公司 | 2022-05-13 | — | — | CN | disclosed |