Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.41 |
| ▸ | LIG1 | P18858 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 8/20 | 0.40 |
| ▸ | HTR2B | P41595 | 6/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2060735 | 1.00 | MAPT (0.43) | MAPTL3MBTL1TSHRHPGDMAPK1 | |
| SCHEMBL26118236 | 0.87 | TSHR (0.53) | MAPTL3MBTL1TSHRHPGDMAPK1 | |
| SCHEMBL9671334 | 0.81 | TSHR (0.45) | MAPTL3MBTL1TSHRHPGDMAPK1 | |
| SCHEMBL5460266 | 0.81 | HTR2C (0.46) | MAPTL3MBTL1TSHRHPGDMAPK1 | |
| SCHEMBL11601509 | 0.81 | HPGD (0.51) | MAPTL3MBTL1TSHRHPGDMAPK1 | |
| SCHEMBL324337 | 0.79 | LIG1 (0.44) | MAPTL3MBTL1TSHRHPGDMAPK1 | |
| SCHEMBL29496131 | 0.79 | LIG1 (0.44) | MAPTL3MBTL1TSHRHPGDMAPK1 | |
| SCHEMBL21728039 | 0.79 | MAPT (0.47) | MAPTL3MBTL1TSHRHPGDMAPK1 | |
| SCHEMBL9869935 | 0.79 | TSHR (0.42) | MAPTL3MBTL1TSHRHPGDMAPK1 | |
| SCHEMBL21736938 | 0.76 | ADRA2A (0.42) | MAPTL3MBTL1TSHRHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |