Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 8/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.43 |
| ▸ | RET | P07949 | 8/20 | 0.42 |
| ▸ | ROS1 | P08922 | 8/20 | 0.42 |
| ▸ | FLT3 | P36888 | 8/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10157222 | 1.00 | EML4 (0.43) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10157374 | 0.95 | ALDH1A1 (0.42) | EML4ALKRETROS1FLT3 | |
| SCHEMBL15759136 | 0.83 | MAPT (0.48) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10035939 | 0.81 | MAPT (0.56) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10157197 | 0.81 | HTR1A (0.45) | FGFR3SMN1; SMN2 | |
| SCHEMBL10157382 | 0.80 | ALDH1A1 (0.44) | FGFR3GAA | |
| SCHEMBL10203102 | 0.80 | ALDH1A1 (0.43) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10155996 | 0.79 | CYP3A4 (0.41) | EML4ALKROS1FLT3FGFR3 | |
| SCHEMBL12127788 | 0.78 | EML4 (0.47) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10157386 | 0.78 | FGFR3 (0.47) | FGFR3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |