Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 5/20 | 0.46 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.39 |
| ▸ | HPGDS | O60760 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29522041 | 1.00 | CRBN (0.46) | CRBNIRAK1IRAK3MEN1ALDH1A1 | |
| SCHEMBL26139423 | 0.87 | CRBN (0.47) | CRBNIRAK1IRAK3MEN1ALDH1A1 | |
| SCHEMBL30042811 | 0.87 | CRBN (0.47) | CRBNIRAK1IRAK3MEN1ALDH1A1 | |
| SCHEMBL27176453 | 0.85 | CRBN (0.48) | CRBNIRAK1IRAK3MEN1ALDH1A1 | |
| SCHEMBL30996469 | 0.82 | IRAK1 (0.48) | CRBNIRAK1IRAK3MEN1ALDH1A1 | |
| SCHEMBL29129961 | 0.82 | IRAK1 (0.47) | CRBNIRAK1IRAK3MEN1ALDH1A1 | |
| SCHEMBL24501060 | 0.81 | CRBN (0.54) | CRBNIRAK1IRAK3MEN1ALDH1A1 | |
| SCHEMBL29648286 | 0.81 | CRBN (0.54) | CRBNIRAK1IRAK3MEN1ALDH1A1 | |
| SCHEMBL23301420 | 0.81 | CRBN (0.72) | CRBNALDH1A1HPGDSARDDB1 | |
| SCHEMBL26822203 | 0.79 | CRBN (0.47) | CRBNIRAK1IRAK3MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022065962-A1 | MLKL BINDING OR DEGRADING COMPOUND AND PHARMACEUTICAL USE THEREOF | 한국화학연구원 | 2022-03-31 | — | — | WO | disclosed |