Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.45 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 4/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 3/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30042811 | 0.88 | CRBN (0.47) | CRBNALDH1A1MEN1MAPTALOX15 | |
| SCHEMBL26139423 | 0.88 | CRBN (0.47) | CRBNALDH1A1MEN1MAPTALOX15 | |
| SCHEMBL30694690 | 0.86 | GPR119 (0.45) | CRBNALDH1A1MEN1MAPTALOX15 | |
| SCHEMBL21907830 | 0.86 | GPR119 (0.45) | CRBNALDH1A1MEN1MAPTALOX15 | |
| SCHEMBL29522041 | 0.85 | CRBN (0.46) | CRBNALDH1A1MEN1MAPTALOX15 | |
| SCHEMBL29522052 | 0.85 | CRBN (0.46) | CRBNALDH1A1MEN1MAPTALOX15 | |
| SCHEMBL24501060 | 0.84 | CRBN (0.54) | CRBNALDH1A1MEN1MAPTALOX15 | |
| SCHEMBL29648286 | 0.84 | CRBN (0.54) | CRBNALDH1A1MEN1MAPTALOX15 | |
| SCHEMBL29129961 | 0.83 | IRAK1 (0.47) | CRBNALDH1A1MEN1MAPTALOX15 | |
| SCHEMBL30996469 | 0.83 | IRAK1 (0.48) | CRBNALDH1A1MEN1MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4340887-A1 | BIFUNCTIONAL PROTAC-TYPE COMPOUNDS TARGETING PXR, METHOD FOR PREPARING SAME, AND THERAPEUTIC USE THEREOF | Centre National de la Recherche Scientifique (FR) | 2024-03-27 | — | — | EP | disclosed |
| WO-2022243365-A1 | BIFUNCTIONAL PROTAC-TYPE COMPOUNDS TARGETING PXR, METHOD FOR PREPARING SAME, AND THERAPEUTIC USE THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2022-11-24 | — | — | WO | disclosed |