Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 5/20 | 0.47 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.45 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 3/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26139423 | 1.00 | CRBN (0.47) | CRBNIRAK1IRAK3ALOX15MEN1 | |
| SCHEMBL30996469 | 0.93 | IRAK1 (0.48) | CRBNIRAK1IRAK3ALOX15MEN1 | |
| SCHEMBL29129961 | 0.89 | IRAK1 (0.47) | CRBNIRAK1IRAK3ALOX15MEN1 | |
| SCHEMBL27176453 | 0.88 | CRBN (0.48) | CRBNIRAK1IRAK3ALOX15MEN1 | |
| SCHEMBL29522052 | 0.87 | CRBN (0.46) | CRBNIRAK1IRAK3ALOX15MEN1 | |
| SCHEMBL29522041 | 0.87 | CRBN (0.46) | CRBNIRAK1IRAK3ALOX15MEN1 | |
| SCHEMBL31547260 | 0.83 | CRBN (0.44) | CRBNIRAK1IRAK3ALOX15MEN1 | |
| SCHEMBL30962345 | 0.82 | CRBN (0.46) | CRBNIRAK1IRAK3ALOX15MEN1 | |
| SCHEMBL24501060 | 0.82 | CRBN (0.54) | CRBNIRAK1IRAK3ALOX15MEN1 | |
| SCHEMBL29648286 | 0.82 | CRBN (0.54) | CRBNIRAK1IRAK3ALOX15MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4107158-A1 | BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF | Nurix Therapeutics, Inc. (US) | 2022-12-28 | — | — | EP | disclosed |
| CN-115335381-A | Bifunctional degradants of interleukin-1 receptor-associated kinase and therapeutic uses thereof | 新锐思生物制药股份有限公司 | 2022-11-11 | — | — | CN | disclosed |