Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.51 |
| ▸ | F7 | P08709 | 1/20 | 0.48 |
| ▸ | F3 | P13726 | 1/20 | 0.48 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.48 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.48 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4280154 | 1.00 | AR (0.62) | ARLCKSMYD3CYP3A4F7 | |
| SCHEMBL6648425 | 0.93 | AR (0.55) | ARLCKSMYD3CYP3A4F7 | |
| SCHEMBL29972759 | 0.93 | AR (0.55) | ARLCKSMYD3CYP3A4F7 | |
| SCHEMBL18318801 | 0.86 | AR (0.64) | ARCYP3A4MAP4K4MKNK1MKNK2 | |
| SCHEMBL113378 | 0.83 | SMYD3 (0.55) | ARSMYD3CYP3A4HIPK2IMPDH2 | |
| SCHEMBL29489099 | 0.83 | SMYD3 (0.55) | ARSMYD3CYP3A4HIPK2IMPDH2 | |
| SCHEMBL2363489 | 0.82 | LCK (0.78) | LCKPLAUKDM4E | |
| SCHEMBL12765931 | 0.81 | SMYD3 (0.50) | ARSMYD3CYP3A4HIPK2IMPDH2 | |
| SCHEMBL3126130 | 0.81 | IMPDH2 (0.53) | ARSMYD3CYP3A4HIPK2IMPDH2 | |
| Hydrochloric Acid SCHEMBL7557776 | 0.81 | SMYD3 (0.54) | ARSMYD3CYP3A4HIPK2IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3536685-B1 | BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS | PFIZER (US) | 2022-02-16 | — | — | EP | claimed |
| WO-2024032715-A1 | HYDRAZIDE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | 深圳微芯生物科技股份有限公司 | 2024-02-15 | — | — | WO | disclosed |
| EP-3640242-B1 | ROCK-INHIBITING COMPOUND AND USES THEREOF | HITGEN LTD (CN) | 2023-04-19 | — | — | EP | disclosed |
| EP-4125900-A1 | METHODS OF TREATING CORONAVIRUS DISEASE 2019 | Pfizer Inc. (US) | 2023-02-08 | — | — | EP | disclosed |
| CN-114423757-A | Tricyclic heteroaryl compounds useful as IRAK4 inhibitors | 百时美施贵宝公司 | 2022-04-29 | — | — | CN | disclosed |