Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 6/20 | 0.55 |
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.49 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.49 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29523427 | 1.00 | LTB4R (0.55) | LTB4RLTB4R2FFAR1ATMSLC6A9 | |
| SCHEMBL29035350 | 1.00 | LTB4R (0.55) | LTB4RLTB4R2FFAR1ATMSLC6A9 | |
| SCHEMBL25364674 | 0.89 | ATM (0.63) | LTB4RLTB4R2FFAR1ATMSLC6A9 | |
| SCHEMBL25362664 | 0.89 | ATM (0.63) | LTB4RLTB4R2FFAR1ATMSLC6A9 | |
| SCHEMBL25362660 | 0.89 | ATM (0.63) | LTB4RLTB4R2FFAR1ATMSLC6A9 | |
| SCHEMBL8947296 | 0.80 | MMP1 (0.68) | MAPK1KDM4EGAAALDH1A1LMNA | |
| SCHEMBL3961994 | 0.80 | GAA (0.59) | GPR139MAPK1KDM4EGAAALDH1A1 | |
| SCHEMBL29035407 | 0.79 | LTB4R (0.57) | LTB4RLTB4R2FFAR1GAAALDH1A1 | |
| SCHEMBL29523345 | 0.79 | LTB4R (0.57) | LTB4RLTB4R2FFAR1GAAALDH1A1 | |
| SCHEMBL29523814 | 0.79 | LTB4R (0.57) | LTB4RLTB4R2FFAR1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4216946-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | Achillion Pharmaceuticals, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| CN-116437913-A | Pharmaceutical compounds for treating complement-mediated disorders | 艾其林医药公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2022066774-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | ACHILLION PHARMACEUTICALS, INC. (US) | 2022-03-31 | — | — | WO | disclosed |