Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29066236 | 1.00 | HSD17B10 (0.44) | HSD17B10NPC1CYP11B1CYP11B2MEN1 | |
| SCHEMBL46303 | 0.84 | HSD17B10 (0.46) | HSD17B10NPC1CYP11B1CYP11B2MEN1 | |
| SCHEMBL29066214 | 0.83 | HSD17B10 (0.41) | HSD17B10NPC1CYP11B1CYP11B2TSHR | |
| SCHEMBL29527139 | 0.83 | HSD17B10 (0.41) | HSD17B10NPC1CYP11B1CYP11B2TSHR | |
| SCHEMBL16914120 | 0.80 | HSD17B10 (0.49) | HSD17B10NPC1CYP11B2MEN1TSHR | |
| SCHEMBL29066185 | 0.74 | KDM4E (0.40) | HSD17B10NPC1MEN1TSHRKMT2A | |
| SCHEMBL29527699 | 0.74 | FFAR1 (0.40) | HSD17B10CYP11B1CYP11B2PIP4K2ATP53 | |
| SCHEMBL29526566 | 0.74 | HSD17B10 (0.34) | HSD17B10NPC1CYP11B1CYP11B2PIP4K2A | |
| SCHEMBL29066188 | 0.74 | FFAR1 (0.40) | HSD17B10CYP11B1CYP11B2PIP4K2ATP53 | |
| SCHEMBL17578977 | 0.71 | MET (0.49) | HSD17B10NPC1TSHRPIP4K2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240730-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| CN-116710443-A | 2-pyridones as thyroid hormone receptor modulators | 阿利戈斯治疗公司 | 2023-09-05 | — | — | CN | disclosed |
| WO-2022099044-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |