Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 8/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 8/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.34 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29066188 | 1.00 | FFAR1 (0.40) | FFAR1FFAR4HSD17B10NPBWR1MCHR1 | |
| SCHEMBL29066224 | 0.87 | SMN1; SMN2 (0.38) | FFAR1FFAR4NPBWR1MCHR1RORC | |
| SCHEMBL29526747 | 0.87 | SMN1; SMN2 (0.38) | FFAR1FFAR4NPBWR1MCHR1RORC | |
| SCHEMBL29527163 | 0.79 | THRA (0.48) | — | |
| SCHEMBL29066161 | 0.79 | THRA (0.48) | — | |
| SCHEMBL29066176 | 0.78 | THRA (0.47) | — | |
| SCHEMBL29527139 | 0.76 | HSD17B10 (0.41) | FFAR1FFAR4HSD17B10CYP11B1CYP11B2 | |
| SCHEMBL29066214 | 0.76 | HSD17B10 (0.41) | FFAR1FFAR4HSD17B10CYP11B1CYP11B2 | |
| SCHEMBL46303 | 0.75 | HSD17B10 (0.46) | FFAR1FFAR4HSD17B10CYP11B1CYP11B2 | |
| SCHEMBL29527271 | 0.74 | HSD17B10 (0.44) | FFAR1FFAR4HSD17B10CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240730-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| CN-116710443-A | 2-pyridones as thyroid hormone receptor modulators | 阿利戈斯治疗公司 | 2023-09-05 | — | — | CN | disclosed |
| WO-2022099044-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |