Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 6/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29527467 | 0.85 | NPBWR1 (0.34) | NPBWR1MCHR1KDM4EALDH1A1TDP1 | |
| SCHEMBL29527017 | 0.82 | MEN1 (0.39) | MEN1KMT2AALDH1A1 | |
| SCHEMBL24600275 | 0.81 | THRB (0.32) | NPBWR1MCHR1 | |
| SCHEMBL23168830 | 0.80 | NPBWR1 (0.40) | NPBWR1MCHR1 | |
| SCHEMBL24407940 | 0.78 | THRB (0.56) | — | |
| SCHEMBL24449327 | 0.77 | NPBWR1 (0.36) | NPBWR1MCHR1 | |
| SCHEMBL29527291 | 0.77 | — | — | |
| SCHEMBL29526904 | 0.77 | NPBWR1 (0.37) | NPBWR1MCHR1 | |
| SCHEMBL24600252 | 0.76 | CREBBP (0.32) | NPBWR1MCHR1MEN1KMT2ABRD4 | |
| SCHEMBL24600445 | 0.74 | PDE4A (0.32) | NPBWR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240730-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| CN-116710443-A | 2-pyridones as thyroid hormone receptor modulators | 阿利戈斯治疗公司 | 2023-09-05 | — | — | CN | disclosed |
| WO-2022099044-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |