⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29527642 | 0.90 | — | — | |
| SCHEMBL29527397 | 0.77 | NPBWR1 (0.34) | — | |
| SCHEMBL24407940 | 0.73 | THRB (0.56) | — | |
| SCHEMBL29527046 | 0.73 | NPBWR1 (0.34) | — | |
| SCHEMBL29526904 | 0.70 | NPBWR1 (0.37) | — | |
| SCHEMBL29066210 | 0.70 | THRA (0.61) | — | |
| SCHEMBL29527017 | 0.69 | MEN1 (0.39) | — | |
| SCHEMBL29527727 | 0.69 | THRB (0.30) | — | |
| SCHEMBL30511714 | 0.68 | CYP3A4 (0.32) | — | |
| SCHEMBL29066201 | 0.67 | THRA (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240730-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022099044-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |