Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.58 |
| ▸ | RAB9A | P51151 | 10/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13258606 | 0.83 | NPC1 (0.67) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL5052689 | 0.79 | NPC1 (0.62) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1665475 | 0.79 | MAPT (0.63) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL18501695 | 0.78 | NPC1 (0.68) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL5270613 | 0.73 | NPC1 (1.00) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7067985 | 0.71 | MAPT (0.74) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7063800 | 0.71 | RAB9A (0.71) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL5055343 | 0.71 | MAPT (0.60) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1664978 | 0.71 | NPC1 (0.58) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL15191540 | 0.70 | NPC1 (0.56) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11278525-B1 | Further molecules, compositions and methods for modulation of SIRT6 | SirTLab Corporation (IL) | 2022-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11278525-B1 | Further molecules, compositions and methods for modulation of SIRT6 | SIRT6, SIRT1, SIRT2 | NPC1 1097/4885RAB9A 1219/4885ALDH1A1 1419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.