Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cloxacillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 0.84 |
| ▸ | HPGD | P15428 | 3/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.70 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cloxacillin SCHEMBL11404593 | 1.00 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL11404577 | 1.00 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL16333855 | 1.00 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL1625107 | 1.00 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL31229061 | 1.00 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL8728823 | 1.00 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL11404582 | 1.00 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL41014 | 0.99 | ABCB11 (0.98) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL28547421 | 0.99 | ABCB11 (0.98) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL5550210 | 0.98 | ABCB11 (0.97) | ABCB11LMNAHPGDCYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 25926 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12637481-B2 | Boronic acid derivatives and therapeutic uses thereof | QPEX BIOPHARMA, INC. (US) | 2026-05-26 | — | — | US | claimed |
| WO-2026106917-A1 | EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL | BioPhysics Pharma, Inc. (US) | 2026-05-21 | — | — | WO | claimed |
| WO-2026104587-A1 | CYCLIC BORONIC ACID ESTERS USEFUL AS ADJUVANTS IN THE TREATMENT OF BACTERIAL INFECTIONS | ADJUTEC PHARMA AS (NO) | 2026-05-21 | — | — | WO | claimed |
| EP-4736859-A1 | ANTIBIOTIC COMPOSITIONS | University of Galway (IE) | 2026-05-06 | — | — | EP | claimed |
| US-20260108619-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2026-04-23 | — | — | US | claimed |
| US-12605345-B2 | Transdermal drug delivery system | BioPhysics Pharma, Inc. (US) | 2026-04-21 | — | — | US | claimed |
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| US-12594365-B2 | Ionic compounds for medical device applications | BECTON, DICKINSON AND COMPANY (US) | 2026-04-07 | — | — | US | claimed |
| US-20260091089-A1 | Pyocyanine Demethylases and related Phenazine Degrading Agents Compositions, Methods and Systems for Interfering with Viability of Bacteria | CALIFORNIA INST OF TECHN (US) | 2026-04-02 | — | — | US | claimed |
| US-20260091127-A1 | JANUS PARTICLE-EMBEDDED MATERIALS FOR ANTIMICROBIAL APPLICATIONS | UNIV INDIANA TRUSTEES (US) | 2026-04-02 | — | — | US | claimed |
| US-4302447-A | Pharmaceutical and dietary composition | EFAMOL LIMITED (GB) | 1981-11-24 | — | — | US | claimed |
| EP-0003407-B1 | PHARMACEUTICAL AND DIETARY COMPOSITION COMPRISING GAMMA-LINOLENIC ACIDS | EFAMOL LIMITED (GB) | 1981-09-30 | — | — | EP | claimed |
| US-4283400-A | Medicated animal feed based on liver meal | BAYER AKTIENGESELLSCHAFT (DE) | 1981-08-11 | — | — | US | claimed |
| US-4273763-A | TREATMENT OF SCHIZOPHRENIA WITH B-LACTAM ANTIBIOTICS | EFAMOL LIMITED (GB) | 1981-06-16 | — | — | US | claimed |
| EP-0029668-A1 | Pharmaceutical injectable composition and two-pack container for said composition | BEECHAM GROUP PLC (GB) | 1981-06-03 | — | — | EP | claimed |
| US-4239745-A | INCUBATION WITH TAGGED ANTIBIOTIC AND ANTIBIOTIC SENSITIVE CELLS | PENICILLIN ASSAYS, INC. (US) | 1980-12-16 | — | — | US | claimed |
| US-4217274-A | Methoxyethoxymethyl esters of penicillins | BRISTOL-MYERS COMPANY (US) | 1980-08-12 | — | — | US | claimed |
| US-4199566-A | DERIVATIVES OF PENICILLANIC ACID | TOYAMA CHEMICAL COMPANY, LIMITED (JP) | 1980-04-22 | — | — | US | claimed |
| EP-0004770-A2 | Pharmaceutical and dietary composition comprising gamma-linolenic acids | EFAMOL LIMITED (GB) | 1979-10-17 | — | — | EP | claimed |
| US-4145429-A | VEGETALBE OIL, CLAY, ANTIBIOTIC | BEECHAM GROUP LIMITED (GB) | 1979-03-20 | — | — | US | claimed |