Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cloxacillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 4/20 | 0.98 |
| ▸ | LMNA | P02545 | 4/20 | 0.83 |
| ▸ | HPGD | P15428 | 3/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.69 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cloxacillin SCHEMBL5550210 | 0.99 | ABCB11 (0.97) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL8728823 | 0.99 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL11404582 | 0.99 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL1625107 | 0.99 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL11404577 | 0.99 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL2953 | 0.99 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL31229061 | 0.99 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL11404593 | 0.99 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL16333855 | 0.99 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL28547421 | 0.98 | ABCB11 (0.98) | ABCB11LMNAHPGDCYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2992 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12274830-B2 | Nitric oxide inhalation therapy for infants with bronchiolitis | BEYOND AIR LTD (IL) | 2025-04-15 | — | — | US | claimed |
| CN-119119083-A | Preparation method of high-purity cloxacillin sodium | 山西双雁药业有限公司 | 2024-12-13 | — | — | CN | claimed |
| CN-119019419-A | Preparation method of high-purity cloxacillin sodium crystal | 天津大学 | 2024-11-26 | — | — | CN | claimed |
| CN-118580255-A | Crystallization method of cloxacillin sodium | 山西双雁药业有限公司 | 2024-09-03 | — | — | CN | claimed |
| US-20240173512-A1 | METHODS FOR POTENTIATING ANTIMICROBIAL AGENTS | STREETERVILLE CAPITAL, LLC | 2024-05-30 | — | — | US | claimed |
| US-20240122859-A1 | EXTENDED RELEASE MULTIPLE UNIT PELLET SYSTEM COMPOSITION AND ITS PROCESS FOR THE PREPARATION | NOKHA TRADING LLP (IN) | 2024-04-18 | — | — | US | claimed |
| US-11890421-B2 | Methods for potentiating antimicrobial agents | BEYOND AIR LTD (IL) | 2024-02-06 | — | — | US | claimed |
| CN-116763783-A | Cloxacillin sodium composition and preparation method thereof | 成都倍特药业股份有限公司 | 2023-09-19 | — | — | CN | claimed |
| WO-2022172225-A1 | EXTENDED RELEASE MULTIPLE UNIT PELLET SYSTEM COMPOSITION AND ITS PROCESS FOR THE PREPARATION | LYRUS LIFE SCIENCES PVT. LTD. (IN) | 2022-08-18 | — | — | WO | claimed |
| US-20220169680-A1 | CELL-PENETRATING PEPTIDE BASED ON INFLUENZA VIRUS M2 PROTEIN | INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2022-06-02 | — | — | US | claimed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | claimed |
| EP-0222712-B1 | VETERINARY COMPOSITIONS CONTAINING ANTIMICROBIAL AGENTS, AND THEIR USE | FATRO S.p.A: (IT) | 1990-06-06 | — | — | EP | claimed |
| EP-0222712-A2 | Veterinary compositions containing antimicrobial agents, and their use | FATRO S.p.A: (IT) | 1987-05-20 | — | — | EP | claimed |
| US-RE31301-E | Intramammary compositions | BEECHAM GROUP P.L.C. (GB) | 1983-07-05 | — | — | US | claimed |
| EP-0010904-B1 | INTRAMAMMARY COMPOSITIONS AND PROCESS FOR THEIR PREPARATION | BEECHAM GROUP PLC (GB) | 1982-05-05 | — | — | EP | claimed |
| US-4324783-A | SYNERGISTIC COMBINATION OF PENCILLINS | TOYAMA CHEMICAL CO., LTD. (JP) | 1982-04-13 | — | — | US | claimed |
| US-4282202-A | Intramammary compositions | BEECHAM GROUP LIMITED (GB) | 1981-08-04 | — | — | US | claimed |
| US-4272438-A | SILYLATING, ACYLATION | GLAXO GROUP LIMITED (GB) | 1981-06-09 | — | — | US | claimed |
| EP-0010904-A2 | Intramammary compositions and process for their preparation | BEECHAM GROUP PLC (GB) | 1980-05-14 | — | — | EP | claimed |
| US-4199566-A | DERIVATIVES OF PENICILLANIC ACID | TOYAMA CHEMICAL COMPANY, LIMITED (JP) | 1980-04-22 | — | — | US | claimed |