Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cloxacillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 0.84 |
| ▸ | HPGD | P15428 | 3/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.70 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cloxacillin SCHEMBL11404593 | 1.00 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL11404577 | 1.00 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL16333855 | 1.00 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL1625107 | 1.00 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL31229061 | 1.00 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL2953 | 1.00 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL11404582 | 1.00 | ABCB11 (1.00) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL41014 | 0.99 | ABCB11 (0.98) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL28547421 | 0.99 | ABCB11 (0.98) | ABCB11LMNAHPGDCYP1A2KMT2A | |
| Cloxacillin SCHEMBL5550210 | 0.98 | ABCB11 (0.97) | ABCB11LMNAHPGDCYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5017566-A | Redox systems for brain-targeted drug delivery | UNIVERSITY OF FLORIDA (US) | 1991-05-21 | — | — | US | claimed |
| US-5002935-A | Inclusion Complexing Hydroxypropylcyclodextrin with a Dihydropyridine-substituted Drug | UNIVERSITY OF FLORIDA (US) | 1991-03-26 | — | — | US | claimed |
| EP-0335545-B2 | Pharmaceutical formulations for parenteral use | UNIV FLORIDA (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5024998-A | Administering in aqueous solution with cyclodextrin derivative | UNIVERSITY OF FLORIDA (US) | 1991-06-18 | — | — | US | disclosed |
| US-4983586-A | Decreasing precipitation at injection site or in lungs or other organs by combining with hydroxypropyl-beta-cyclodextrin | UNIVERSITY OF FLORIDA (US) | 1991-01-08 | — | — | US | disclosed |
| EP-0335545-A2 | Pharmaceutical formulations for parenteral use | UNIVERSITY OF FLORIDA (US) | 1989-10-04 | — | — | EP | disclosed |