Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | CBFB | Q13951 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | TYK2 | P29597 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2951931 | 0.78 | PRKDC (0.42) | DHFRXDHIGF1RCDK1CDK2 | |
| SCHEMBL2946044 | 0.76 | MAPT (0.43) | DHFRPOLBCDK1CDK2ATR | |
| SCHEMBL2952943 | 0.75 | MAP2K7 (0.45) | PIK3CAPRKDC | |
| SCHEMBL2946368 | 0.75 | PRKDC (0.40) | DHFRXDHCDK1CDK2MAPT | |
| SCHEMBL2953061 | 0.69 | DHFR (0.42) | ADKDHFRPOLBCDK1CDK2 | |
| SCHEMBL24170032 | 0.68 | AR (0.48) | ADKJAK2JAK1TYK2JAK3 | |
| SCHEMBL521049 | 0.67 | PIK3CA (0.56) | ADKDHFRPOLBKDM4EMEN1 | |
| SCHEMBL29964578 | 0.66 | PIK3CA (0.57) | ADKXDHJAK2JAK1TYK2 | |
| SCHEMBL2558872 | 0.65 | DHFR (0.60) | ADKDHFRCDK1CDK2PIK3CA | |
| SCHEMBL2949706 | 0.65 | PIK3CA (0.57) | DHFRPOLBKDM4EMAPTPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |