Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.39 |
| ▸ | MTOR | P42345 | 4/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.39 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.39 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 2/20 | 0.38 |
| ▸ | PRKCA | P17252 | 2/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2951931 | 0.84 | PRKDC (0.42) | PRKDCPIK3CAADORA2AADORA1DHFR | |
| SCHEMBL2952943 | 0.82 | MAP2K7 (0.45) | PRKDCPIK3CA | |
| SCHEMBL2946044 | 0.80 | MAPT (0.43) | PRKDCADORA2AADORA1DHFRCDK1 | |
| SCHEMBL2953053 | 0.75 | ADK (0.42) | PRKDCPIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1893213 | 0.73 | PARP1 (0.50) | PIK3R1PIK3CDPIK3C2BPIK3CB | |
| SCHEMBL2946373 | 0.71 | DHFR (0.43) | PRKDCPIK3CAMTORPIK3R1PIK3CD | |
| SCHEMBL2946549 | 0.70 | CDK1 (0.32) | ADORA2AADORA1DHFRCDK1CDK2 | |
| SCHEMBL2946541 | 0.70 | CDK1 (0.41) | ADORA2AADORA1DHFRCDK1CDK2 | |
| SCHEMBL2955281 | 0.69 | CAMKK2 (0.45) | ADORA2ANPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL2012672 | 0.69 | LGMN (0.61) | PRKDCPIK3CAMTORPIK3R1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |