Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NME4 | O00746 | 1/20 | 0.40 |
| ▸ | GCDH | Q92947 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 2/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 9/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22846285 | 1.00 | NME4 (0.40) | NME4GCDHSIRT5MAPTSNCA | |
| SCHEMBL22846544 | 0.87 | NME4 (0.43) | NME4GCDHSIRT5MAPTSNCA | |
| SCHEMBL29531028 | 0.87 | NME4 (0.43) | NME4GCDHSIRT5MAPTSNCA | |
| SCHEMBL22834286 | 0.85 | NME4 (0.41) | NME4GCDHSIRT5MAPTSNCA | |
| SCHEMBL22834008 | 0.85 | NME4 (0.42) | NME4GCDHSIRT5MAPTSNCA | |
| SCHEMBL29531124 | 0.84 | NME4 (0.41) | NME4GCDHSIRT5MAPTSNCA | |
| SCHEMBL22846286 | 0.84 | NME4 (0.41) | NME4GCDHSIRT5MAPTSNCA | |
| SCHEMBL22834275 | 0.83 | NME4 (0.40) | NME4GCDHSIRT5MAPTSNCA | |
| SCHEMBL22834173 | 0.82 | MAPT (0.47) | NME4GCDHSIRT5MAPTSNCA | |
| SCHEMBL29450892 | 0.82 | LDHA (0.34) | MIFLDHAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3994262-A1 | ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS | Stratos Genomics Inc. (US) | 2022-05-11 | — | — | EP | claimed |
| CN-119823106-A | Enhanced nucleic acid polymerization by aromatic compounds | 豪夫迈·罗氏有限公司 | 2025-04-15 | — | — | CN | disclosed |
| US-20250075265-A1 | ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS | ROCHE SEQUENCING SOLUTIONS INC (US) | 2025-03-06 | — | — | US | disclosed |
| CN-114144520-B | Enhanced nucleic acid polymerization by aromatic compounds | 豪夫迈·罗氏有限公司 | 2024-12-13 | — | — | CN | disclosed |
| US-11970731-B2 | Enhancement of nucleic acid polymerization by aromatic compounds | Roche Sequencing Solutions, Inc. (US) | 2024-04-30 | — | — | US | disclosed |
| EP-3994262-A1 | ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS | Stratos Genomics Inc. (US) | 2022-05-11 | — | — | EP | disclosed |
| US-20220112548-A1 | ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS | Roche Sequencing Solutions, Inc. | 2022-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11970731-B2 | Enhancement of nucleic acid polymerization by aromatic compounds | POLN, POLB, POLRMT | NME4 139/4885GCDH 1933/4885SIRT5 4709/4885 |
| US-20250075265-A1 | ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS | POLN, POLB, POLRMT | NME4 139/4885GCDH 1933/4885SIRT5 4709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.