Bradykinin

SCHEMBL29530927

CC(=O)O.NC(N)=NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)O

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2A ADRA2B ADRA2C ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CALCR CHRNA3 CHRNB4 ESR1 ESR2 GHSR GNRHR GSC1 HSPA8 MALT1 MC1R MC4R NOS1 NOS2 NOS3 OPRK1 OXTR RAMP1 RAMP2 RAMP3 SCN5A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 dacA dacB dacC folP ftsI mrcA mrcB mrdA rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Bradykinin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 6)

	gene	UniProt	supporting neighbours	confidence
▸	BDKRB2 known ✓	P30411	12/20	0.79

▸	F2	P00734	1/20	0.68

▸	OPRM1	P35372	1/20	0.60

▸	OPRD1	P41143	1/20	0.60

▸	PREP	P48147	1/20	0.58

▸	MRGPRX2	Q96LB1	1/20	0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Bradykinin SCHEMBL3047797	0.98	BDKRB2 (0.82)	BDKRB2F2OPRM1OPRD1PREP
SCHEMBL29404860	0.96	BDKRB2 (0.79)	BDKRB2F2OPRM1OPRD1PREP
SCHEMBL29484957	0.96	BDKRB2 (0.79)	BDKRB2F2OPRM1OPRD1PREP
SCHEMBL29929851	0.94	BDKRB2 (0.74)	BDKRB2F2OPRD1
SCHEMBL29599233	0.93	BDKRB2 (0.74)	BDKRB2PREPMRGPRX2
SCHEMBL29497762	0.92	BDKRB2 (0.77)	BDKRB2F2PREP
SCHEMBL150645	0.92	BDKRB2 (0.83)	BDKRB2F2OPRD1PREPMRGPRX2
SCHEMBL1649860	0.92	BDKRB2 (0.83)	BDKRB2F2OPRD1PREPMRGPRX2
SCHEMBL20298701	0.91	BDKRB2 (0.75)	BDKRB2F2OPRM1OPRD1PREP
SCHEMBL20298769	0.91	BDKRB2 (0.81)	BDKRB2F2OPRD1PREPMRGPRX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2025054616-A1	PLATFORM APPROACH F-18 RADIOLABELING OF VARIOUS PEPTIDES IN AQUEOUS MEDIUM	MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US)	2025-03-13	—	—	WO	disclosed
US-20250057836-A1	Compositions And Methods Targeting G12 Signaling For Bronchodilator Therapy	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	2025-02-20	—	—	US	disclosed
US-20230356185-A1	IMPROVEMENTS IN LIQUID CHROMATOGRAPHY SUBSTRATES	UNIVERSITY OF SOUTH AUSTRALIA (AU)	2023-11-09	—	—	US	disclosed
EP-4217106-A1	IMPROVEMENTS IN LIQUID CHROMATOGRAPHY SUBSTRATES	University Of South Australia (AU)	2023-08-02	—	—	EP	disclosed
US-20230092870-A1	MARGARIC ACID DECREASES PIEZ02-MEDIATED PAIN	The United States of America, as represented by the Secretary, Deparment of Health and Human Services	2023-03-23	—	—	US	disclosed
EP-4103153-A1	MARGARIC ACID DECREASES PIEZ02-MEDIATED PAIN	United States of America, as represented by The Secretary, Department of Health and Human Services (US)	2022-12-21	—	—	EP	disclosed
WO-2022061418-A9	IMPROVEMENTS IN LIQUID CHROMATOGRAPHY SUBSTRATES	UNIVERSITY OF SOUTH AUSTRALIA (AU)	2022-04-28	—	—	WO	disclosed
WO-2022061418-A1	IMPROVEMENTS IN LIQUID CHROMATOGRAPHY SUBSTRATES	UNIVERSITY OF SOUTH AUSTRALIA (AU)	2022-03-31	—	—	WO	disclosed