Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29532316 | 0.90 | SMN1; SMN2 (0.62) | NPC1RAB9ASMN1; SMN2PKMEPHX2 | |
| SCHEMBL29532645 | 0.87 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2PKMEPHX2 | |
| SCHEMBL20989092 | 0.86 | MEN1 (0.56) | NPC1RAB9ASMN1; SMN2PKMEPHX2 | |
| SCHEMBL19705237 | 0.85 | SMN1; SMN2 (0.67) | NPC1RAB9ASMN1; SMN2PKMEPHX2 | |
| SCHEMBL29532384 | 0.84 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2PKMEPHX2 | |
| SCHEMBL20989077 | 0.83 | MEN1 (0.58) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL23975373 | 0.82 | SMN1; SMN2 (0.89) | NPC1RAB9ASMN1; SMN2PKMEPHX2 | |
| SCHEMBL20989192 | 0.82 | RECQL (0.58) | NPC1RAB9ASMN1; SMN2PKMEPHX2 | |
| SCHEMBL29532540 | 0.81 | RAB9A (0.59) | NPC1RAB9ASMN1; SMN2PKMEPHX2 | |
| SCHEMBL20989104 | 0.80 | MEN1 (0.53) | NPC1RAB9ASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468960-B1 | CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2022-03-23 | — | — | EP | claimed |
| EP-3468960-B1 | CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2022-03-23 | — | — | EP | disclosed |