Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29532316 | 0.91 | SMN1; SMN2 (0.62) | SMN1; SMN2PKMNPC1RAB9AEPHX2 | |
| SCHEMBL29532260 | 0.87 | NPC1 (0.62) | SMN1; SMN2PKMNPC1RAB9AEPHX2 | |
| SCHEMBL19705237 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2PKMNPC1RAB9AEPHX2 | |
| SCHEMBL29532384 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2PKMNPC1RAB9AEPHX2 | |
| SCHEMBL29532540 | 0.82 | RAB9A (0.59) | SMN1; SMN2PKMNPC1RAB9AEPHX2 | |
| SCHEMBL20989201 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2FKBP1AMAPTENPP2L3MBTL1 | |
| SCHEMBL20989092 | 0.79 | MEN1 (0.56) | SMN1; SMN2PKMNPC1RAB9AEPHX2 | |
| SCHEMBL19692617 | 0.78 | KMT2A (0.59) | SMN1; SMN2PKMNPC1RAB9AEPHX2 | |
| SCHEMBL20989310 | 0.77 | L3MBTL1 (0.50) | SMN1; SMN2FKBP1AMAPTL3MBTL1KMT2A | |
| SCHEMBL20989077 | 0.76 | MEN1 (0.58) | SMN1; SMN2NPC1RAB9AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468960-B1 | CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2022-03-23 | — | — | EP | claimed |
| EP-3468960-B1 | CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2022-03-23 | — | — | EP | disclosed |