Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29532260 | 0.86 | NPC1 (0.62) | MEN1KMT2AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL20989077 | 0.81 | MEN1 (0.58) | MEN1KMT2AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL29532316 | 0.81 | SMN1; SMN2 (0.62) | MEN1KMT2AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL20989171 | 0.81 | POLB (0.63) | KMT2AKDM4ESMN1; SMN2POLBALDH1A1 | |
| SCHEMBL20989192 | 0.80 | RECQL (0.58) | MEN1KMT2AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL29532645 | 0.79 | SMN1; SMN2 (0.56) | MEN1KMT2AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL20989076 | 0.79 | SMN1; SMN2 (0.53) | MEN1KMT2AMAPTSMN1; SMN2POLB | |
| SCHEMBL29532384 | 0.78 | SMN1; SMN2 (0.52) | MEN1KMT2AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL20989104 | 0.78 | MEN1 (0.53) | MEN1KMT2AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL5367904 | 0.76 | ME2 (0.56) | MEN1KMT2AKDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190134056-A1 | K-RAS MUTATIONS AND ANTAGONISTS | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOG (US) | 2019-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190134056-A1 | K-RAS MUTATIONS AND ANTAGONISTS | KRAS, NRAS, HRAS | MEN1 1465/4885KMT2A 2604/4885KDM4E 4410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.