Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3343124 | 1.00 | ALDH1A1 (0.59) | ALDH1A1KDM4EHTTTSHRRECQL | |
| SCHEMBL15652183 | 0.86 | ALDH1A1 (0.65) | ALDH1A1HTTTSHRMEN1KMT2A | |
| SCHEMBL1003525 | 0.84 | ALDH1A1 (0.63) | ALDH1A1HTTTSHRMEN1KMT2A | |
| SCHEMBL15651824 | 0.82 | PKM (0.56) | ALDH1A1HTTTSHRMEN1KMT2A | |
| SCHEMBL15650298 | 0.82 | POLB (0.61) | HTTTSHRLMNASMN1; SMN2POLB | |
| SCHEMBL16888223 | 0.81 | ALDH1A1 (0.52) | ALDH1A1KDM4EHTTTSHRRECQL | |
| SCHEMBL20568836 | 0.81 | ALDH1A1 (0.52) | ALDH1A1KDM4EHTTTSHRRECQL | |
| SCHEMBL847277 | 0.81 | POLB (0.69) | ALDH1A1KDM4EHTTTSHRMEN1 | |
| SCHEMBL29257268 | 0.79 | ALDH1A1 (0.45) | ALDH1A1HTTTSHRHPGDMEN1 | |
| SCHEMBL1196165 | 0.78 | TSHR (0.63) | ALDH1A1KDM4EHTTTSHRRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228624-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 Therapeutics, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081927-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |