Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 6/20 | 0.46 |
| ▸ | PGR | P06401 | 5/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.46 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | SHBG | P04278 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261966 | 0.86 | AR (0.50) | ARPGRNR3C2SERPINA6ALDH1A1 | |
| SCHEMBL2833823 | 0.81 | AR (0.51) | ARPGRNR3C2SERPINA6ALDH1A1 | |
| SCHEMBL29335494 | 0.81 | AR (0.51) | ARPGRNR3C2SERPINA6ALDH1A1 | |
| SCHEMBL29335775 | 0.79 | AR (0.51) | ARPGRNR3C2SERPINA6ALDH1A1 | |
| SCHEMBL13216960 | 0.79 | AR (0.48) | ARPGRNR3C2SERPINA6ALDH1A1 | |
| SCHEMBL2965005 | 0.78 | AR (0.63) | ARPGRNR3C2SERPINA6ALDH1A1 | |
| SCHEMBL29335510 | 0.78 | AR (0.49) | ARPGRNR3C2SERPINA6ALDH1A1 | |
| SCHEMBL13474752 | 0.78 | AR (0.49) | ARPGRNR3C2SERPINA6ALDH1A1 | |
| SCHEMBL30140884 | 0.78 | SHBG (0.59) | ARPGRNR3C2SERPINA6ALDH1A1 | |
| SCHEMBL2832958 | 0.78 | SHBG (0.59) | ARPGRNR3C2SERPINA6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772218-B2 | Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one | SRI INTERNATIONAL (US) | 2010-08-10 | — | — | US | disclosed |
| US-20050009801-A1 | Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one | PETERS RICHARD H (US) | 2005-01-13 | — | — | US | disclosed |
| US-6784170-B2 | TREATMENT OF PROSTATE DISORDERS SUCH AS PROSTATIC CANCER | SRI INTERNATIONAL | 2004-08-31 | — | — | US | disclosed |
| WO-2001058919-A9 | SYNTHESIS OF ANTI-ESTROGENIC AND OTHER THERAPEUTIC STEROIDS FROM 21-HYDROXY-19-NORPREGNA-4-EN-3-ONE | STANFORD RES INST INT (US) | 2002-01-03 | — | — | WO | disclosed |
| US-20010039269-A1 | Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one | SRI INTERNATIONAL | 2001-11-08 | — | — | US | disclosed |
| WO-2001058919-A2 | SYNTHESIS OF ANTI-ESTROGENIC AND OTHER THERAPEUTIC STEROIDS FROM 21-HYDROXY-19-NORPREGNA-4-EN-3-ONE | SRI INTERNATIONAL (US) | 2001-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010039269-A1 | Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one | NR5A1, HSD17B11, CYP17A1 | AR 12/4885PGR 35/4885NR3C2 26/4885 |
| US-20050009801-A1 | Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one | CYP17A1, NR5A1, HSD17B11 | AR 9/4885PGR 32/4885NR3C2 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.