Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 2/20 | 0.72 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TCF4 | P15884 | 1/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | FABP4 | P15090 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ACLY | P53396 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24102933 | 1.00 | WDR5 (0.72) | WDR5GFERTDP1MAPTHPGD | |
| SCHEMBL28538527 | 0.87 | WDR5 (0.73) | WDR5TDP1POLBHSD17B10FABP4 | |
| SCHEMBL29535080 | 0.87 | WDR5 (0.64) | WDR5GFERTDP1MAPTHPGD | |
| SCHEMBL24102866 | 0.87 | WDR5 (0.64) | WDR5GFERTDP1MAPTHPGD | |
| SCHEMBL24102922 | 0.86 | TCF4 (0.68) | WDR5MAPTHPGDTCF4CTNNB1 | |
| SCHEMBL24102304 | 0.83 | WDR5 (0.59) | WDR5GFERTDP1MAPTHPGD | |
| SCHEMBL29535093 | 0.83 | WDR5 (0.59) | WDR5GFERTDP1MAPTHPGD | |
| SCHEMBL11025715 | 0.80 | POLB (0.78) | MAPTPOLBTCF4CTNNB1MEN1 | |
| SCHEMBL1030477 | 0.79 | GFER (0.83) | GFERTDP1MAPTHPGDPOLB | |
| SCHEMBL5178749 | 0.77 | WDR5 (0.54) | WDR5TDP1HPGDPOLBFABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111285806-B | Pyrazole compound and preparation method, application and pharmaceutical composition thereof | 中国医学科学院药物研究所 | 2022-04-15 | — | — | CN | disclosed |