Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.46 |
| ▸ | GABRP | O00591 | 4/20 | 0.46 |
| ▸ | GABRD | O14764 | 4/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.46 |
| ▸ | GABRE | P78334 | 4/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.46 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.46 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.46 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.46 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.41 |
| ▸ | PDE9A | O76083 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24343867 | 1.00 | PDE10A (0.47) | PDE10AIMPDH2GABRPGABRDGABRA1 | |
| SCHEMBL24344158 | 0.83 | GABRP (0.50) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL29534384 | 0.83 | GABRP (0.50) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL29534435 | 0.76 | TUBB4A (0.43) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL24343894 | 0.76 | TUBB4A (0.43) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL24343875 | 0.74 | CYP11B2 (0.40) | SQORHTTKDM4EALDH1A1HPGD | |
| SCHEMBL29534909 | 0.74 | CYP11B2 (0.40) | SQORHTTKDM4EALDH1A1HPGD | |
| SCHEMBL24343830 | 0.70 | KDM4E (0.61) | IMPDH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29534260 | 0.70 | KDM4E (0.61) | IMPDH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL26351986 | 0.70 | TLR9 (0.45) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119019388-A | 5-And 6-azaindole compounds for inhibiting Bcr-Abl tyrosine kinase | 英莱汶公司 | 2024-11-26 | — | — | CN | disclosed |
| EP-4225742-A1 | 5- AND 6-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES | Enliven Therapeutics, Inc. (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076975-A1 | 5- AND 6-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |