Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | AGPAT2 | O15120 | 8/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22719071 | 1.00 | POLB (0.51) | POLBAGPAT2NR1I2AHRHPGD | |
| SCHEMBL13730480 | 0.85 | RPS27 (0.46) | POLBAGPAT2KDM4EPIK3CAMTOR | |
| SCHEMBL24814667 | 0.79 | POLB (0.57) | POLBAGPAT2NR1I2AHRHPGD | |
| SCHEMBL29535900 | 0.78 | MAOA (0.51) | POLBAGPAT2NFKB1MAPTNPC1 | |
| SCHEMBL22719062 | 0.78 | MAOA (0.51) | POLBAGPAT2NFKB1MAPTNPC1 | |
| SCHEMBL7833949 | 0.77 | ALDH1A1 (0.38) | POLBHPGDKDM4EPIK3CAMTOR | |
| SCHEMBL11803401 | 0.73 | KDM4E (0.41) | POLBHPGDKDM4ENFKB1PIK3CA | |
| SCHEMBL6797215 | 0.72 | MAPK8 (0.51) | POLBKDM4EMAPTHTTRAB9A | |
| SCHEMBL2195003 | 0.72 | EGFR (0.43) | HPGDTP53MAPTNPC1HTT | |
| SCHEMBL2193858 | 0.70 | SMN1; SMN2 (0.44) | POLBHPGDTP53MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976611-A1 | HETEROBICYCLIC INHIBITORS OF MAT2A AND METHODS OF USE FOR TREATING CANCER | Les Laboratoires Servier (FR) | 2022-04-06 | — | — | EP | disclosed |