Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 6/20 | 0.40 |
| ▸ | CDK7 | P50613 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.38 |
| ▸ | MARK3 | P27448 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | CLK2 | P49760 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.38 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24285969 | 1.00 | LRRK2 (0.45) | LRRK2RIPK1ABL1MAP4K1CDK8 | |
| SCHEMBL24285848 | 0.94 | LRRK2 (0.47) | LRRK2RIPK1ABL1MAP4K1CDK8 | |
| SCHEMBL29537003 | 0.94 | LRRK2 (0.47) | LRRK2RIPK1ABL1MAP4K1CDK8 | |
| SCHEMBL29537535 | 0.84 | JAK1 (0.36) | ABL1PIK3CAJAK2 | |
| SCHEMBL24285931 | 0.84 | JAK1 (0.34) | CDK8CCNCROCK2PAK4CDK2 | |
| SCHEMBL29537272 | 0.84 | JAK1 (0.34) | CDK8CCNCROCK2PAK4CDK2 | |
| SCHEMBL24285879 | 0.84 | JAK1 (0.36) | ABL1PIK3CAJAK2 | |
| SCHEMBL24285977 | 0.83 | LRRK2 (0.59) | LRRK2RIPK1ABL1MAP4K1CDK8 | |
| SCHEMBL29537401 | 0.83 | LRRK2 (0.59) | LRRK2RIPK1ABL1MAP4K1CDK8 | |
| SCHEMBL24285984 | 0.78 | RIPK1 (0.47) | LRRK2RIPK1MAP4K1CDK8CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4214207-A1 | 2-AMINO-3-CARBONYL IMIDAZOPYRIDINE AND PYRAZOLOPYRIDINE COMPOUNDS | 1st Biotherapeutics, Inc. (KR) | 2023-07-26 | — | — | EP | claimed |
| CN-116457355-A | 2-amino-3-carbonyl imidazopyridines and pyrazolopyridines compounds | 第一生物治疗股份有限公司 | 2023-07-18 | — | — | CN | claimed |
| WO-2022058890-A1 | 2-AMINO-3-CARBONYL IMIDAZOPYRIDINE AND PYRAZOLOPYRIDINE COMPOUNDS | 1ST Biotherapeutics, Inc. (KR) | 2022-03-24 | — | — | WO | claimed |