Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30106474 | 0.84 | TP53 (0.34) | TP53MAPTALOX15HSD17B10CYP2C9 | |
| SCHEMBL29426193 | 0.81 | NPSR1 (0.34) | TP53MAPTNPSR1NFKB1NFKB2 | |
| SCHEMBL30309243 | 0.74 | TP53 (0.37) | TP53MAPTALOX15HSD17B10CYP2C9 | |
| SCHEMBL30106494 | 0.72 | — | — | |
| SCHEMBL30106489 | 0.72 | — | — | |
| SCHEMBL30336772 | 0.72 | ALDH1A1 (0.40) | MAPTALOX15HSD17B10 | |
| SCHEMBL30106565 | 0.69 | TP53 (0.32) | TP53MAPTALOX15HSD17B10CYP2C9 | |
| SCHEMBL27902873 | 0.68 | TP53 (0.33) | TP53MAPTALOX15HSD17B10 | |
| SCHEMBL28537050 | 0.67 | TP53 (0.38) | TP53MAPTALOX15HSD17B10CYP2C9 | |
| SCHEMBL28537049 | 0.67 | ALOX15 (0.38) | TP53MAPTALOX15HSD17B10CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110475777-B | Novel pyrido [2,3-b ] indole compounds for the treatment and prevention of bacterial infections | 豪夫迈·罗氏有限公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-114364684-A | Heterocyclic compounds | 豪夫迈·罗氏有限公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-109790169-B | Cyanopyrrolidine derivatives having activity as USP30 inhibitors | 特殊治疗有限公司 | 2022-03-29 | — | — | CN | disclosed |