Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 7/20 | 0.39 |
| ▸ | BAZ2A | Q9UIF9 | 7/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.34 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29544272 | 0.82 | BAZ2B (0.38) | BAZ2BBAZ2ABRD4BRD2BRD3 | |
| SCHEMBL19127286 | 0.79 | SMN1; SMN2 (0.48) | KMT2ARAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL23889130 | 0.78 | ELANE (0.39) | BAZ2BBAZ2ABRD4BRD2BRD3 | |
| SCHEMBL23889156 | 0.78 | RAB9A (0.42) | BAZ2BBAZ2ABRD4BRD2BRD3 | |
| SCHEMBL29543833 | 0.77 | ALDH1A1 (0.43) | KMT2ARAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL7936130 | 0.76 | NPC1 (0.46) | FEN1KMT2ARAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL30039983 | 0.73 | HDAC1 (0.38) | FEN1RAB9ANPC1 | |
| SCHEMBL23089333 | 0.73 | KDM4E (0.35) | FEN1HDAC8KMT2ARAB9AALDH1A1 | |
| SCHEMBL3549382 | 0.72 | NPC1 (0.59) | BAZ2BBAZ2ABRD4BRD2BRD3 | |
| SCHEMBL20067076 | 0.70 | RAB9A (0.37) | BAZ2BBAZ2ABRD4BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269742-B | Derivatives of 4- (imidazo [1,2-a ] pyridin-3-yl) -N- (pyridinyl) pyrimidin-2-amine as therapeutic agents | 常州千红生化制药股份有限公司 | 2024-07-16 | — | — | CN | disclosed |
| EP-3997088-A1 | DERIVATIVES OF 4-(IMIDAZO[L,2-A]PYRIDIN-3-YL)-N-(PYRIDINYL)PYRIMIDIN- 2-AMINE AS THERAPEUTIC AGENTS | Aucentra Therapeutics Pty Ltd (AU) | 2022-05-18 | — | — | EP | disclosed |