Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 6/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17024799 | 1.00 | CFD (0.41) | CFDPKMKMT2ACREBBPALDH1A1 | |
| SCHEMBL17037519 | 0.92 | CFD (0.41) | CFDPKMKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL29545967 | 0.87 | CFD (0.47) | CFDKMT2ACREBBPALDH1A1SMN1; SMN2 | |
| SCHEMBL18555261 | 0.87 | CFD (0.47) | CFDKMT2ACREBBPALDH1A1SMN1; SMN2 | |
| SCHEMBL29545307 | 0.86 | PKM (0.39) | CFDPKMKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL17024802 | 0.86 | PKM (0.39) | CFDPKMKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL17037526 | 0.84 | CFD (0.43) | CFDKMT2ACREBBPALDH1A1SMN1; SMN2 | |
| SCHEMBL21756797 | 0.83 | HDAC8 (0.38) | KMT2AALDH1A1FTOP2RX3 | |
| SCHEMBL18555825 | 0.81 | CFD (0.39) | CFDCREBBPALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL18578356 | 0.81 | CFD (0.45) | CFDKMT2ACREBBPALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4053117-A1 | ARYL, HETEROARYL, AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS | Achillion Pharmaceuticals, Inc. (US) | 2022-09-07 | — | — | EP | disclosed |
| CN-114044800-A | Aryl, heteroaryl and heterocyclic compounds for the treatment of medical disorders | 艾其林医药公司 | 2022-02-15 | — | — | CN | disclosed |