Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Doxycycline Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP7 known ✓ | P09237 | 1/20 | 0.70 |
| ▸ | MMP8 known ✓ | P22894 | 1/20 | 0.70 |
| ▸ | MMP13 known ✓ | P45452 | 1/20 | 0.70 |
| ▸ | MMP2 | P08253 | 1/20 | 0.70 |
| ▸ | MMP3 | P08254 | 1/20 | 0.70 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.69 |
| ▸ | USP2 | O75604 | 6/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.68 |
| ▸ | RECQL | P46063 | 7/20 | 0.65 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.65 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxycycline Anhydrous SCHEMBL3155 | 1.00 | MMP2 (0.70) | MMP2MMP3MMP7MMP8ADORA1 | |
| Doxycycline Anhydrous SCHEMBL41884 | 1.00 | MMP2 (0.70) | MMP2MMP3MMP7MMP8ADORA1 | |
| Doxycycline Anhydrous SCHEMBL2221981 | 1.00 | MMP2 (0.70) | MMP2MMP3MMP7MMP8ADORA1 | |
| Doxycycline Anhydrous SCHEMBL11417262 | 1.00 | MMP2 (0.70) | MMP2MMP3MMP7MMP8ADORA1 | |
| Doxycycline Anhydrous SCHEMBL3680869 | 1.00 | MMP2 (0.70) | MMP2MMP3MMP7MMP8ADORA1 | |
| Doxycycline Anhydrous SCHEMBL41883 | 1.00 | MMP2 (0.70) | MMP2MMP3MMP7MMP8ADORA1 | |
| Doxycycline Anhydrous SCHEMBL28250743 | 1.00 | MMP2 (0.70) | MMP2MMP3MMP7MMP8ADORA1 | |
| Doxycycline Anhydrous SCHEMBL11417256 | 1.00 | MMP2 (0.70) | MMP2MMP3MMP7MMP8ADORA1 | |
| Doxycycline Anhydrous SCHEMBL8683380 | 1.00 | MMP2 (0.70) | MMP2MMP3MMP7MMP8ADORA1 | |
| Doxycycline Anhydrous SCHEMBL497163 | 0.99 | TDP1 (0.69) | MMP2MMP3MMP7MMP8ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230372328-A1 | ORAL DELAYED BURST FORMULATION OF LOW-DOSE NALTREXONE AND METHODS FOR TREATING FIBROMYALGIA AND LONG COVID | ACQUIOM AGENCY SERVICES LLC, AS AGENT | 2023-11-23 | — | — | US | disclosed |
| EP-4225312-A1 | ORAL DELAYED BURST FORMULATION OF LOW-DOSE NALTREXONE OR NALOXONE USED FOR TREATING FIBROMYALGIA AND LONG COVID | Scilex Holding Company (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076470-A1 | ORAL DELAYED BURST FORMULATION OF LOW-DOSE NALTREXONE OR NALOXONE USED FOR|TREATING FIBROMYALGIA AND LONG COVID | SORRENTO THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230372328-A1 | ORAL DELAYED BURST FORMULATION OF LOW-DOSE NALTREXONE AND METHODS FOR TREATING FIBROMYALGIA AND LONG COVID | OPRK1, OPRL1, OPRM1 | MMP7 2547/4885MMP8 3262/4885MMP13 2795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.