Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.62 |
| ▸ | MAOB | P27338 | 4/20 | 0.62 |
| ▸ | ACHE | P22303 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
| ▸ | RORA | P35398 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23148499 | 0.84 | CYP1A2 (0.56) | CYP1A2CYP2C19RORARORCRORB | |
| SCHEMBL22907401 | 0.81 | METAP2 (0.42) | MAOAMAOBACHECYP2D6ROCK2 | |
| SCHEMBL29547892 | 0.81 | METAP2 (0.42) | MAOAMAOBACHECYP2D6ROCK2 | |
| SCHEMBL20128560 | 0.80 | METAP2 (0.49) | ROCK2CYP11B2METAP2 | |
| SCHEMBL19009222 | 0.78 | MAOA (0.68) | MAOAMAOBACHECYP2D6GRIN1 | |
| SCHEMBL20128580 | 0.76 | METAP2 (0.48) | METAP2 | |
| SCHEMBL16120111 | 0.75 | MAOA (0.73) | MAOAMAOBACHECYP2D6GRIN1 | |
| SCHEMBL30961770 | 0.75 | CYP17A1 (0.42) | MAOAMAOBACHEROCK2CYP1A2 | |
| SCHEMBL22906784 | 0.75 | METAP2 (0.47) | ROCK2CYP11B2METAP2 | |
| SCHEMBL17265051 | 0.74 | MAOA (0.62) | MAOAMAOBACHECYP2D6GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3999182-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2022-05-25 | — | — | EP | disclosed |