Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 11/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | MAOA | P21397 | 5/20 | 0.41 |
| ▸ | MAOB | P27338 | 5/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22907401 | 1.00 | METAP2 (0.42) | METAP2ROCK2MAOAMAOBACHE | |
| SCHEMBL29547747 | 0.81 | MAOA (0.62) | METAP2ROCK2MAOAMAOBACHE | |
| SCHEMBL22152176 | 0.80 | MAOA (0.54) | MAOAMAOBACHECYP2D6 | |
| SCHEMBL20128560 | 0.79 | METAP2 (0.49) | METAP2ROCK2 | |
| SCHEMBL20128580 | 0.78 | METAP2 (0.48) | METAP2 | |
| SCHEMBL22906784 | 0.77 | METAP2 (0.47) | METAP2ROCK2 | |
| SCHEMBL22906719 | 0.76 | METAP2 (0.47) | METAP2 | |
| SCHEMBL22906538 | 0.76 | METAP2 (0.47) | METAP2ROCK2 | |
| SCHEMBL20128570 | 0.76 | METAP2 (0.47) | METAP2ROCK2 | |
| SCHEMBL27098819 | 0.74 | ROCK2 (0.39) | METAP2ROCK2MAOAMAOBACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3999182-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2022-05-25 | — | — | EP | disclosed |