Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | LPL | P06858 | 3/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24270108 | 1.00 | HTR1D (0.33) | HTR1DMAPK1CSF1RLPLLIPG | |
| SCHEMBL24270206 | 0.92 | HIF1A (0.32) | MAPK1CSF1RHIF1A | |
| SCHEMBL29547787 | 0.92 | HIF1A (0.32) | MAPK1CSF1RHIF1A | |
| SCHEMBL24270178 | 0.88 | CSF1R (0.33) | CSF1RLPLLIPGHIF1A | |
| SCHEMBL24269646 | 0.85 | HIF1A (0.34) | MAPK1CSF1RLPLLIPGHIF1A | |
| SCHEMBL24270223 | 0.84 | PDE2A (0.33) | MAPK1HIF1ACYP11B2 | |
| SCHEMBL22290862 | 0.80 | LIPG (0.42) | HTR1DMAPK1LPLLIPG | |
| SCHEMBL2981753 | 0.79 | HTR1D (0.40) | HTR1DCYP11B2 | |
| SCHEMBL15774984 | 0.79 | LPL (0.45) | MAPK1LPLLIPG | |
| SCHEMBL16196633 | 0.79 | CYP11B2 (0.37) | HTR1DMAPK1LPLLIPGCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022068848-A1 | 3-[(1H-PYRAZOL-4-YL)OXY]PYRAZIN-2-AMINE COMPOUNDS AS HPK1 INHIBITOR AND USE THEREOF | BEIGENE, LTD. (KY) | 2022-04-07 | — | — | WO | disclosed |