Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.55 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | FER | P16591 | 1/20 | 0.55 |
| ▸ | LTK | P29376 | 1/20 | 0.55 |
| ▸ | CDK8 | P49336 | 1/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10627555 | 1.00 | LRRK2 (0.55) | LRRK2ACVR1MAOAMAOBPDGFRA | |
| SCHEMBL10713179 | 0.90 | LRRK2 (0.46) | LRRK2ACVR1MAOAMAOBPDGFRA | |
| SCHEMBL6670395 | 0.89 | MAOA (0.62) | LRRK2ACVR1MAOAMAOBPDGFRA | |
| SCHEMBL29409246 | 0.82 | GSK3B (0.62) | LRRK2ACVR1MAOAMAOBPDGFRA | |
| SCHEMBL29011572 | 0.76 | LRRK2 (0.36) | LRRK2ACVR1MAOAMAOBPDGFRA | |
| SCHEMBL2420711 | 0.75 | LRRK2 (0.90) | LRRK2ACVR1MAOAMAOBPDGFRA | |
| SCHEMBL366728 | 0.75 | — | — | |
| SCHEMBL11546561 | 0.74 | TGM2 (0.61) | LRRK2MAOAMAOBIDO1TGM2 | |
| SCHEMBL6428222 | 0.74 | CSNK1G1 (0.45) | LRRK2ACVR1MAOAMAOBALDH1A1 | |
| SCHEMBL1964262 | 0.74 | LRRK2 (0.46) | LRRK2MAOAMAOBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118146227-A | Synthesis method of spiro indolone derivative | 中国科学院大连化学物理研究所 | 2024-06-07 | — | — | CN | claimed |
| CN-110551057-B | Chiral 3,3-disubstituted oxindole derivative and synthesis method and application thereof | 华东师范大学 | 2023-02-07 | — | — | CN | claimed |
| CN-115028645-A | Synthesis method of bisindolone [ spiro ] benzodihydrofuran compound | 河南师范大学 | 2022-09-09 | — | — | CN | claimed |
| CN-113185523-B | Synthetic method of 3-indolone [ spiro ] -3H-indole compound | 河南师范大学 | 2022-04-08 | — | — | CN | claimed |
| CN-121135732-A | Indolone spiro pyrroline compound, synthesis method thereof and anticancer activity | 河南师范大学 | 2025-12-16 | — | — | CN | disclosed |
| CN-118146227-A | Synthesis method of spiro indolone derivative | 中国科学院大连化学物理研究所 | 2024-06-07 | — | — | CN | disclosed |
| CN-117567353-A | Indolone spironorcarane diene compound with anticancer activity and preparation method and application thereof | 常州大学 | 2024-02-20 | — | — | CN | disclosed |
| CN-110551057-B | Chiral 3,3-disubstituted oxindole derivative and synthesis method and application thereof | 华东师范大学 | 2023-02-07 | — | — | CN | disclosed |
| CN-110551057-B | Chiral 3,3-disubstituted oxindole derivative and synthesis method and application thereof | 华东师范大学 | 2023-02-07 | — | — | CN | disclosed |
| CN-115028645-A | Synthesis method of bisindolone [ spiro ] benzodihydrofuran compound | 河南师范大学 | 2022-09-09 | — | — | CN | disclosed |
| CN-115028645-A | Synthesis method of bisindolone [ spiro ] benzodihydrofuran compound | 河南师范大学 | 2022-09-09 | — | — | CN | disclosed |
| CN-113185523-B | Synthetic method of 3-indolone [ spiro ] -3H-indole compound | 河南师范大学 | 2022-04-08 | — | — | CN | disclosed |
| CN-113185523-B | Synthetic method of 3-indolone [ spiro ] -3H-indole compound | 河南师范大学 | 2022-04-08 | — | — | CN | disclosed |