Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.34 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 3/20 | 0.32 |
| ▸ | BACE1 | P56817 | 3/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29548138 | 0.85 | CAMKK1 (0.34) | DRD2HTR1BHTR6CAMKK1CAMKK2 | |
| SCHEMBL29548514 | 0.81 | GPR119 (0.44) | — | |
| SCHEMBL29548852 | 0.81 | CAMKK1 (0.34) | DRD2HTR1BHTR6CAMKK1CAMKK2 | |
| SCHEMBL29548592 | 0.78 | SMYD2 (0.31) | CAMKK1CAMKK2 | |
| SCHEMBL29548910 | 0.76 | CAMKK1 (0.36) | DRD2HTR1BHTR6CAMKK1CAMKK2 | |
| SCHEMBL29549132 | 0.75 | CAMKK1 (0.35) | DRD2HTR1BHTR6CAMKK1CAMKK2 | |
| SCHEMBL29549089 | 0.75 | CAMKK1 (0.32) | CAMKK1CAMKK2JAK1JAK3KCNH2 | |
| SCHEMBL29549126 | 0.65 | PDE10A (0.34) | CAMKK1CAMKK2 | |
| SCHEMBL29548203 | 0.60 | CAMKK1 (0.38) | CAMKK1CAMKK2 | |
| SCHEMBL22650905 | 0.60 | PIK3CA (0.47) | CAMKK1CAMKK2JAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022070288-A1 | NITROGEN-CONTAINING BICYCLIC COMPOUND | 旭化成ファーマ株式会社 | 2022-04-07 | — | — | WO | disclosed |