Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 2/20 | 0.35 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.34 |
| ▸ | GLRB | P48167 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17678260 | 1.00 | LRRK2 (0.42) | LRRK2PRMT5FABP4PRKCIGLRA3 | |
| SCHEMBL17673642 | 0.85 | HSD17B10 (0.42) | FABP4PRKCIATMHSD17B10HCAR1 | |
| SCHEMBL13967316 | 0.85 | HCAR1 (0.50) | LRRK2PRMT5FABP4PRKCIHSD17B10 | |
| SCHEMBL31228863 | 0.83 | GAA (0.50) | ATMHSD17B10HCAR1GAAMEN1 | |
| SCHEMBL17678098 | 0.83 | GAA (0.47) | PRKCIATMHSD17B10HCAR1GAA | |
| SCHEMBL15833538 | 0.81 | LRRK2 (0.42) | LRRK2PRMT5PRKCIGLRA3GLRB | |
| SCHEMBL15833718 | 0.81 | GAA (0.52) | ATMHSD17B10MAPTHCAR1GAA | |
| SCHEMBL15824855 | 0.81 | PRKCI (0.51) | PRMT5FABP4PRKCIHSD17B10MAPT | |
| SCHEMBL31144588 | 0.81 | GAA (0.52) | ATMHSD17B10MAPTHCAR1GAA | |
| SCHEMBL15823728 | 0.80 | FABP4 (0.40) | PRMT5FABP4PRKCIGLRA3GLRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596051-B1 | FUSED BICYCLIC COMPOUNDS, COMPOSITIONS AND APPLICATIONS THEREOF | IMPETIS BIOSCIENCES LTD (IN) | 2022-04-27 | — | — | EP | disclosed |