Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.40 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.39 |
| ▸ | HINT1 | P49773 | 6/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | TK1 | P04183 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6889007 | 0.90 | TK1 (0.43) | PNPHINT1ADORA3TK1HPGD | |
| SCHEMBL28167650 | 0.90 | ADORA3 (0.42) | PNPHINT1ADORA3TK1HPGD | |
| SCHEMBL30343036 | 0.89 | ADORA3 (0.42) | PNPHPRT1HINT1ADORA3TK1 | |
| SCHEMBL5347482 | 0.89 | ADORA3 (0.42) | PNPHPRT1HINT1ADORA3TK1 | |
| SCHEMBL8198286 | 0.89 | ADORA3 (0.42) | PNPHPRT1HINT1ADORA3TK1 | |
| SCHEMBL28319357 | 0.89 | ADORA3 (0.44) | PNPHINT1ADORA3TK1HPGD | |
| SCHEMBL8678720 | 0.88 | HINT1 (0.41) | PNPHPRT1HINT1ADORA3HPGD | |
| SCHEMBL5611914 | 0.85 | ADORA3 (0.46) | PNPHINT1ADORA3TK1HPGD | |
| SCHEMBL5561293 | 0.84 | ADORA3 (0.39) | PNPHPRT1HINT1ADORA3TK1 | |
| SCHEMBL6826568 | 0.84 | ADORA3 (0.45) | PNPHINT1ADORA3TK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100151458-A1 | OLIGORIBONUCLEOTIDES AND RIBONUCLEASES FOR CLEAVING RNA | ISIS PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | US | disclosed |
| US-7695902-B2 | Oligoribonucleotides and ribonucleases for cleaving RNA | ISIS PHARMACEUTICALS, INC. (US) | 2010-04-13 | — | — | US | disclosed |
| US-7629321-B2 | Oligoribonucleotides and oligoribonucleosides that have subsequences of 2'-pentoribofuranosyl nucleosides that activate dsRNase (double stranded RNAase) | ISIS PHARMACEUTICALS, INC. (US) | 2009-12-08 | — | — | US | disclosed |
| US-7432250-B2 | Oligoribonucleotides and ribonucleases for cleaving RNA | ISIS PHARMACEUTICALS, INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432249-B2 | Oligoribonucleotides and ribonucleases for cleaving RNA | ISIS PHARMACEUTICALS, INC. (US) | 2008-10-07 | — | — | US | disclosed |
| EP-1621545-A2 | Oligoribonucleotides and ribonucleases for cleaving RNA | Isis Pharmaceuticals, Inc. (US) | 2006-02-01 | — | — | EP | disclosed |
| EP-1600506-A2 | Oligoribonucleotides and ribonucleases for cleaving RNA | Isis Pharmaceuticals, Inc. (US) | 2005-11-30 | — | — | EP | disclosed |
| EP-0928290-B9 | OLIGORIBONUCLEOTIDES AND RIBONUCLEASES FOR CLEAVING RNA | ISIS PHARMACEUTICALS INC (US) | 2005-11-09 | — | — | EP | disclosed |
| EP-0928290-B1 | OLIGORIBONUCLEOTIDES AND RIBONUCLEASES FOR CLEAVING RNA | ISIS PHARMACEUTICALS INC (US) | 2005-03-30 | — | — | EP | disclosed |
| US-20040191773-A1 | Oligoribonucleotides and ribonucleases for cleaving RNA | ISIS PHARMACEUTICALS INC. | 2004-09-30 | — | — | US | disclosed |
| US-20030119777-A1 | Oligoribonucleotides and ribonucleases for cleaving RNA | ISIS PHARMACEUTICALS, INC. | 2003-06-26 | — | — | US | disclosed |
| US-20030096784-A1 | Oligoribonucleotides and ribonucleases for cleaving RNA | ISIS PHARMACEUTICALS, INC. | 2003-05-22 | — | — | US | disclosed |
| US-20030096286-A1 | Oligoribonucleotides and ribonucleases for cleaving RNA | ISIS PHARMACEUTICALS, INC. | 2003-05-22 | — | — | US | disclosed |
| US-20030096287-A1 | Oligoribonucleotides and ribonucleases for cleaving RNA | IONIS PHARMACEUTICALS, INC. | 2003-05-22 | — | — | US | disclosed |
| US-20020165189-A1 | Oligoribonucleotides and ribonucleases for cleaving RNA | ISIS PHARMACEUTICALS, INC. | 2002-11-07 | — | — | US | disclosed |
| US-6107094-A | IN VITRO MODIFICATION OF TARGET RNA BY CONTACTING SOLUTION OF TARGET AND RIBONUCLEASE PREFERENTIAL FOR DOUBLE-STRANDED RNA WITH OLIGONUCLEOTIDE COMPLEMENTARY TO TARGET AND INCLUDING NUCLEOTIDES MODIFIED TO IMPROVE AFFINITY/SPECIFICITY | ISIS PHARMACEUTICALS, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| US-5898031-A | Oligoribonucleotides for cleaving RNA | ISIS PHARMACEUTICALS, INC. (US) | 1999-04-27 | — | — | US | disclosed |