Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22789664 | 0.91 | KDM1A (0.44) | KDM1AGABRDGABRA1GABRB1GABRA5 | |
| SCHEMBL31657080 | 0.91 | KDM1A (0.44) | KDM1AGABRDGABRA1GABRB1GABRA5 | |
| Trifluoroacetic Acid SCHEMBL30695741 | 0.82 | KDM1A (0.39) | KDM1A | |
| SCHEMBL30948434 | 0.81 | ALDH1A1 (0.46) | KDM1AGABRDGABRA1GABRB1GABRA5 | |
| SCHEMBL30948433 | 0.81 | ALDH1A1 (0.46) | KDM1AGABRDGABRA1GABRB1GABRA5 | |
| SCHEMBL18153851 | 0.76 | KDM1A (0.49) | KDM1AOPRM1OPRD1OPRK1SIRT2 | |
| SCHEMBL23811615 | 0.73 | OTUD7B (0.41) | KDM1APDK2GABRDGABRA1GABRB1 | |
| SCHEMBL29604529 | 0.73 | OTUD7B (0.41) | KDM1APDK2GABRDGABRA1GABRB1 | |
| SCHEMBL21084088 | 0.72 | ALDH1A1 (0.44) | KDM1ANAMPT | |
| SCHEMBL21084148 | 0.72 | ALDH1A1 (0.44) | KDM1ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12209074-B2 | SHP2 phosphatase allosteric inhibitor | BEIJING SHENOGEN PHARMA GROUP LTD. (CN) | 2025-01-28 | — | — | US | disclosed |
| US-20220388977-A1 | SHP2 PHOSPHATASE ALLOSTERIC INHIBITOR | BEIJING SHENOGEN PHARMA GROUP LTD. (CN) | 2022-12-08 | — | — | US | disclosed |
| EP-3984999-A1 | SHP2 PHOSPHATASE ALLOSTERIC INHIBITOR | Beijing Shenogen Pharma Group Ltd. (CN) | 2022-04-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220388977-A1 | SHP2 PHOSPHATASE ALLOSTERIC INHIBITOR | PTPN1, PTPN5, PTPN18 | KDM1A 931/4885PDK2 1951/4885GABRD 2308/4885 |
| US-12209074-B2 | SHP2 phosphatase allosteric inhibitor | PTPN1, PTPN5, PTPN18 | KDM1A 931/4885PDK2 1951/4885GABRD 2308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.