Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.41 |
| ▸ | KDM1A | O60341 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30948434 | 1.00 | ALDH1A1 (0.46) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL21084088 | 0.91 | ALDH1A1 (0.44) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL21084148 | 0.91 | ALDH1A1 (0.44) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL22789664 | 0.86 | KDM1A (0.44) | KDM1AGABRDGABRA1GABRB1GABRA5 | |
| SCHEMBL31657080 | 0.86 | KDM1A (0.44) | KDM1AGABRDGABRA1GABRB1GABRA5 | |
| SCHEMBL18148400 | 0.84 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL18148340 | 0.84 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL23811615 | 0.82 | OTUD7B (0.41) | ALDH1A1KDM1AGABRDGABRA1GABRB1 | |
| SCHEMBL29604529 | 0.82 | OTUD7B (0.41) | ALDH1A1KDM1AGABRDGABRA1GABRB1 | |
| Trifluoroacetic Acid SCHEMBL29550714 | 0.81 | KDM1A (0.39) | KDM1AGABRDGABRA1GABRB1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250223285-A1 | NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | JACOBIO PHARMACEUTICALS CO LTD (CN) | 2025-07-10 | — | — | US | claimed |
| US-12233062-B2 | Heterocyclic derivatives useful as SHP2 inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2025-02-25 | — | — | US | disclosed |
| US-20240285617-A1 | NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2024-08-29 | — | — | US | disclosed |
| US-20240245681-A1 | HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | JACOBO PHARMACEUTICATS CO LTD (CN) | 2024-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250223285-A1 | NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | PTPN5, PTPN1, PTPRJ | ALDH1A1 2690/4885KDM4E 1233/4885MAPT 4283/4885 |
| US-20240245681-A1 | HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | PTPN1, PTPN5, PTPN2 | ALDH1A1 2877/4885KDM4E 685/4885MAPT 3358/4885 |
| US-20240285617-A1 | NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | PTPN1, PTPN5, PTPN2 | ALDH1A1 3226/4885KDM4E 635/4885MAPT 3510/4885 |
| US-12233062-B2 | Heterocyclic derivatives useful as SHP2 inhibitors | PTPN1, PTPN5, PTPN2 | ALDH1A1 2877/4885KDM4E 685/4885MAPT 3358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.